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CT guided radioactive seed 125I implantation in treating lung metastasis
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIOLOGY
- Issue:
- 9
- DOI:
- 10.3760/j.issn:1005-1201.2004.09.003
- Key Word:
- 碘放射性同位素;放射学,介入性;近距离放射疗法;肿瘤转移;肺肿瘤;评价研究
Abstract： 目的评价CT导向下125I粒子植入治疗肺转移瘤的临床价值.方法 18例肺转移瘤患者,男10例,女8例,年龄35～73岁,中位年龄56.2岁,其中肝癌肺转移10例,直肠癌肺转移6例, 乳腺癌肺转移2例.18例病灶数为68个,平均每人3.8个病灶,病灶平均直径为2.5 cm.在CT导向下将125I粒子植入肺转移瘤灶内,采用治疗计划系统(TPS)计算布源;对残留厚度≤1.0 cm的肿瘤选择平面植入方法,采用18.5～29.6 MBq活度的125I粒子相隔1.0～1.5 cm平面播植,125I在1.7 cm内具有杀灭肿瘤的作用.结果 18例68个病灶,完全缓解(CR) 36个;部分缓解(PR) 17个;无变化(NC) 10个;进展(PD) 5个.总有效率77.9%.术中肺内有少量渗出;2例出现气胸,肺压缩均在30%以内,经保守治疗好转;术后1周痰中带血15例.2个月随访过程中发生粒子移位2例(肺内);白细胞下降2例,程度较轻,计数均在3×109/L以上.未见其他严重并发症.结论放射性粒子植入治疗肺部转移瘤临床疗效好,创伤小,并发症发生率低.
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