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Functional magnetic resonance imaging of schizophrenic patients and comparison subjects during a verbal fluency task
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIOLOGY
- Issue:
- 6
- DOI:
- 10.3760/j.issn:1005-1201.2004.06.004
- Key Word:
- 精神分裂症;磁共振成像;语言试验;评价研究
Abstract： 目的应用功能磁共振成像研究正常人和精神病患者在进行词语流畅作业测验时其额、颞叶皮层激活情况的差异.方法8位志愿者和13名精神分裂症患者接受词语流畅作业测验.受试者执行任务时,应用GE 1.5 T Signa Horizon LX超导型磁共振仪,采集其脑部的血氧水平依赖-功能磁共振成像(BOLD-fMRI)数据.刺激序列被分成6个时相,每个时相30s,通过使用Block激活模式,即休息和刺激状态交替.结果对两组额叶、颞叶激活区面积(包括额上回、额中回及额下回)和激活区出现比例(包括颞上回、颞中回及颞下回)进行比较,精神分裂症组左侧额叶激活较正常组的明显减少;正常组左侧额叶较右侧有明显增加,P＜0.05.而颞叶各脑回的精神分裂症患者与正常对照组及左右各对应脑回之间激活情况相仿,P＜0.05.结论fMRI对检测对照组和精神分裂症患者之间完成高级认知作业时的大脑皮层激活差异具有重要价值.
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