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Establishment and bronchial arteriography of the models of canine lung cancer
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIOLOGY
- Issue:
- 10
- DOI:
- 10.3760/j.issn:1005-1201.2003.10.004
- Key Word:
- 肺肿瘤;模型,动物;支气管动脉;血管造影术
Abstract： 目的探讨犬肺癌模型的制作与支气管动脉造影.为肺癌进一步诊断和治疗创造条件.方法 22只犬经气管插管由同轴微导管精确定位,向右肺膈叶灌注甲基胆蒽(MCA)、二乙基亚硝胺(DEN)和超液化碘油混悬液3 ml.随机分为5组,A(4只)、B(4只)、C(4只)、D(5只)、E组(5只);分别观察至1、3、6、12、18个月时处死,观察不同时期病理和影像学变化.对观察18个月的5只犬行支气管动脉造影.结果 1个月时可见细支气管周围炎,肺不张;3个月后逐渐形成慢性肉芽肿性炎症,肺组织纤维化;6～12个月时出现细支气管内干细胞增生,肺组织不典型增生;18个月时分化为鳞癌和细支气管肺泡癌.18个月诱导5只犬的肺癌及癌前相关损害,成功4只.5只犬支气管动脉造影检查,3只支气管动脉向肿瘤供血.结论经气管插管由同轴微导管精确定位灌注MCA、DEN和超液化碘油混悬液诱导犬肺癌模型,定位准确,诱导成功率高;证实犬肺癌模型由支气管动脉供血;支气管动脉造影对肺癌早期诊断具有一定意义.犬肺癌模型对肺癌诊断与治疗,尤其是血管介入治疗的深入研究具有重要意义.
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