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Experimental study of embolization by self-made copper coils in rabbits′ iliac and renal arteries
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIOLOGY
- Issue:
- 3
- DOI:
- 10.3760/j.issn:1005-1201.2003.03.003
- Key Word:
- 铜;栓塞,治疗性;动物,实验;对比研究
Abstract： 目的探讨自制铜圈对兔髂、肾动脉的栓塞作用.方法自制铜圈、弹簧钢圈、丝线分置体外抗凝血皿中,观察其促凝血性.20只兔一侧髂、肾动脉用铜圈栓塞,另侧髂动脉用医用钢丝栓塞作对照,术后不同时间观察血管闭塞情况及其病理学改变;测肝、肾功能及血清铜离子浓度.结果体外实验示铜圈有较强的促凝血作用.血管造影示铜圈闭塞动脉效果优于钢丝,差异有非常显著性意义(P<0.01).病理检查表明铜圈能早期诱发血栓且较钢丝明显差异有非常显著性意义(P<0.05);铜圈对周围组织的影响与钢丝对比不明显,差异无显著性意义(P>0.05).血液铜离子术后3 d 较术前升高,差异有显著性意义(P<0.05), 1周后与栓前比较,差异无显著性意义(P>0.05);肝、肾功能2周后恢复至术前水平.结论自制铜圈对活体兔髂、肾动脉栓塞效果好,无明显毒副反应.
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