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Comparative imaging study on monkeys with hemi-parkinsonism
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIOLOGY
- Issue:
- 1
- DOI:
- 10.3760/j.issn:1005-1201.2003.01.001
- Key Word:
- 帕金森病;动物,实验;诊断显像;对比研究
Abstract： 目的探讨实验性帕金森病(Parkinson disease,PD)的影像学表现及比较不同影像学检查对诊断PD的价值.方法经一侧颈内动脉注射1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP),制作8只偏侧PD猴模型,均于术前及术后行CT、MRI和单光子发射计算机体层摄影术(包括多巴胺转运蛋白显像及局部脑血流显像).1只猴于术前、3只猴术后行正电子发射计算机体层摄影术(葡萄糖代谢显像)检查.结果所有动物均成功制成偏侧PD模型.多巴胺转运蛋白显像见术侧纹状体放射性核素摄取较术前明显减低、亦明显低于对侧.葡萄糖代谢显像见PD组术侧纹状体、丘脑平均标准摄取值低于对侧及健康猴,而对侧较健康猴无明显减低.局部脑血流显像显示偏侧PD猴无局部脑血流灌注异常.MRI上正常老年猴基底节区可无异常信号,也可见苍白球呈双侧对称性窄条状低信号,但无壳核低信号.术后第3个月PD猴壳核及苍白球新出现低信号或苍白球原窄条状低信号区扩大.术前、术后MRI均未见黑质区信号异常及脑萎缩征象.CT未见异常.结论多巴胺转运蛋白显像及葡萄糖代谢显像均能早期显示实验性PD纹状体多巴胺转运蛋白下调或纹状体与丘脑葡萄糖代谢减低.MRI能发现PD基底节区信号减低,但相对较晚.PD局部脑血流显像及CT未能发现异常.
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