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Transarterial infusion chemotherapy with a combination of gemcitabine and 5-fluorouracil in advanced pancreatic carcinoma
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIOLOGY
- Issue:
- 12
- DOI:
- 10.3760/j.issn:1005-1201.2002.12.004
- Key Word:
- 放射学,介入性;胰腺肿瘤;抗肿瘤药;氟尿嘧啶
Abstract： 目的回顾性分析经动脉灌注盐酸吉西他滨(Gemcitabine hydrochloride,商品名健择)和5-氟尿嘧啶(5- fluorouracil,5-Fu)治疗中晚期胰腺癌的临床疗效.方法对22例中晚期胰腺癌患者动脉灌注化疗,采用Seldinger法,动脉插管后选择性置管于胰腺癌的供血动脉内,灌注健择和5-Fu,治疗间隔为3周,随访观察临床受益反应(clinical benefit response, CBR)、肿瘤情况和病人的生存时间. 结果 22例患者的临床受益率为36.4%,客观缓解率为13.6%,Kaplan-Meier法计算6个月和9个月的累积生存率分别为54.6%和28.4%,频数分布法计算中位生存期为6.1个月,中位疾病进展期为2.9个月.结论经动脉灌注健择和5-Fu治疗中晚期胰腺癌可获得较好的临床受益反应,有可能提高患者的生存期.
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