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Intra-tumor basis and influential factors of pleural indentation in peripheral lung cancer
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIOLOGY
- Issue:
- 10
- DOI:
- 10.3760/j.issn:1005-1201.2001.10.002
- Key Word:
- 肺肿瘤;胸膜;因素分析,统计学
Abstract： 目的探讨周围型肺癌胸膜凹陷征形成的瘤内基础及相关影响因素.方法周围型肺癌86例,按有无胸膜凹陷征分为实验组(34例)和对照组(52例),并分析其间质情况;然后对7个变量(瘤内纤维化、肿瘤-胸壁距离、组织学类型、肿瘤大小、分化程度、淋巴结转移及患者性别)分别进行单因素及Logistic回归模型多因素相关分析.结果 (1)胶原纤维为瘤内主要间质纤维,实验组高于对照组(t=3.074,P＜0.01);实验组Ⅰ型胶原含量高于对照组(t=2.896,P＜0.01),成纤维母细胞百分含量高于对照组(χ2=10.785,P＜0.05).(2)实验组瘤内纤维化程度高于对照组(t=3.074,P＜0.01),瘤-壁距离及瘤灶直径均小于对照组(t=5.444,2.874,P＜0.01),两组组织类型构成不同(χ2=13.53,P＜0.01);(3)Logistic回归模型分析发现,影响胸膜凹陷形成的主要因素依次为瘤内纤维化(/=6.851,P＜0.01)、瘤-壁距离(χ2=6.684,P＜0.01)、组织类型(χ2=5.338,P=0.021),与肿瘤大小、分化程度、淋巴结转移及性别无明显关系(χ2=0.000,2.308,1.116,3.034,P＞0.05).结论周围型肺癌胸膜凹陷征形成的主要基础是间质Ⅰ型胶原纤维,成纤维母细胞为主要间质细胞基础;影响因素主要为瘤内纤维化、瘤-壁距离和组织类型,瘤内纤维化为根本的内因,肺癌组织类型影响胸膜凹陷的形成,瘤-壁距离为重要的外因.
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