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Retrospective study of chemoradiotherapy based on cisplatin compared with radiotherapy alone for cervical cancer
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 11
- DOI:
- 10.3760/j.issn:0529-567x.2007.11.002
- Key Word:
- 宫颈肿瘤;顺铂;抗肿瘤联合化疗方案;放射疗法
Abstract： 目的 对比分析单纯放疗及应用以顺铂为主的同步放化疗治疗宫颈癌初治患者的疗效和并发症.方法 选择2000-2006年北京妇产医院收治的初治宫颈癌患者共197例,临床分期为Ⅰb～Ⅳa期,按治疗方法不同分为单纯放疗组(共100例,给予60Co盆腔外照射及192Ir腔内后装照射)和同步放化疗组(共97例,给予以顺铂为主的化疗,同步给予放疗,放疗方案与单纯放疗组相同),对两组患者的疗效及并发症发生情况进行对比分析.结果 单纯放疗组与同步放化疗组有效率分别为92%和89%,两组比较,差异无统计学意义(P=0.500);其5年生存率分别为82%和79%,两组比较,差异无统计学意义(P=0.177).单纯放疗组和同步放化疗组中Ⅲ期以上、病理分级G3、鳞癌患者的5年生存率分别为56%和84%,两组比较,差异有统计学意义(P＜0.01);同步放化疗组和单纯组的近期并发症均以骨髓抑制为主,其中Ⅲ度以上骨髓抑制的发生率分别为14%和3%,两组比较,差异有统计学意义(P＜0.01);其远期并发症的发生率分别为11%和8%,两组比较,差异无统计学意义(P=0.496).结论 应用以顺铂为主的同步放化疗治疗Ⅲ期以上、病理分级G3、鳞癌患者可明显提高其5年生存率.
- [1]张月,侯良宝,陈红.放化疗同步治疗晚期宫颈癌83例临床分析[J].2006,(2).
- [2]Mitra D,Kar A,Ghosh B,etc.Role of chemoradiotherapy in advanced carcinoma cervix.[J].2006,104(8).
- [3]孙建衡.妇科恶性肿瘤继续教育教程[M].2007.
- [4]Rose PG.Combined-modality therapy of locally advanced cervical cancer.[J].2003,21(10 Suppl.).
- [5]殷蔚伯 谷铣之.肿瘤放射治疗学[M].2002.
- [6]Stuart G,MacLean G,Drouin P,etc.Phase III trial comparing radical radiotherapy with and without cisplatin chemotherapy in patients with advanced squamous cell cancer of the cervix.[J].2002,20(4).
- [7]周际昌.实用肿瘤内科学[M].2001.
- [8]Johnsson A,Mattsson S,Norrgren K,etc.Antitumor effect of radioactive cisplatin (191Pt) on nude mice.[J].2001,49(3).
- [9]Peters WA-3rd,Liu PY,Barrett RJ-2nd,etc.Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix.[J].2000,18(8).
- [10]乐杰.妇产科学[M].1998.