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Changes of maternal plasma and umbilical cord plasma inhibin and epidermal growth factor in patients with hypertensive disorder complicating pregnancy
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 8
- DOI:
- 10.3760/j.issn:0529-567X.2006.08.005
- Key Word:
- 妊娠并发症,心血管;高血压;抑制素类;表皮生长因子;酶联免疫吸附测定
Abstract： 目的 探讨妊娠期高血压疾病孕妇血及其分娩的新生儿脐血血浆中抑制素(INH)和表皮生长因子(EGF)的水平变化及其对妊娠期高血压疾病发病及胎儿生长发育的影响.方法 采用酶联免疫吸附试验(ELISA),检测65例妊娠期高血压疾病患者(观察组)及21例正常妊娠妇女(对照组)及其分娩的新生儿脐血血浆中INH、EGF水平.结果 观察组孕妇血浆INH水平为(499±52)ng/L,对照组为(421±36)ng/L,两组比较,差异有统计学意义(P＜0.01).观察组新生儿脐血INH水平为(274±53)ng/L,对照组为(252±28)ng/L,两组比较,差异无统计学意义(P＞0.05).观察组EGF水平为(408±60)ng/L,对照组为(463±87)ng/L,两组比较,差异有统计学意义(P＜0.05).观察组新生儿脐血中EGF水平为(232±99)ng/L,对照组为(380±97)ng/L,两组比较,差异也有统计学意义(P＜0.01).脐血中EGF水平与新生儿体重呈正相关关系(r=0.326,P＜0.05),与胎盘重量呈正相关关系(r=0.451,P＜0.05).结论 孕妇血浆中INH、EGF水平与妊娠期高血压疾病的发病有关,脐血中EGF水平对胎儿及胎盘的生长发育有影响.
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