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Predictive value of serum soluble fms-like tyrosine kinase 1 concentration in preeclampsia at second trimester
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 7
- DOI:
- 10.3760/j.issn:0529-567X.2006.07.001
- Key Word:
- 子痫前期;血管内皮生长因子;受体
Abstract： 目的 探讨血清可溶性血管内皮生长因子受体1(sFlt-1)水平变化对子痫前期的早期预测价值.方法 采用酶联免疫吸附法检测172例妊娠26～28周孕妇的血清sFlt-1及血管内皮生长因子(VEGF)水平,并随访至分娩,其中16例发展为子痫前期(子痫前期组),另外156例正常妊娠者为对照组.结果 子痫前期组患者血清sFlt-1、VEGF分别为(11.4±6.2)μg/L、(26±4)ng/L,对照组分别为(4.5±2.1)μg/L、(29±4)ng/L,两组sFlt-1水平比较,差异有统计学意义(P＜0.01);两组VEGF水平比较,差异无统计学意义(P＞0.05).伴胎儿生长受限的子痫前期患者(8例)及妊娠32周前发病的子痫前期患者(6例)血清sFlt-1水平分别为(14.0±6.8)、(14.4±6.7)μg/L,均分别明显高于未伴胎儿生长受限及妊娠32周后发病的子痫前期患者的(9.0±4.1)、(8.9±4.0)μg/L,差异有统计学意义(P＜0.05).以sFlt-1水平8.75μg/L为界限值,预测子痫前期的敏感度为87.5%,特异度为97.4%,阳性预测值为80.0%,阴性预测值为88.5%.结论 血清sFlt-1水平可作为子痫前期发病的早期预测指标.
- [1]Hirota Y,Yano T,Taketani Y,etc.Elevated Serum Soluble Vascular Endothelial Growth Factor Receptor 1 (sVEGFR-1) Levels in Women with Preeclampsia.[J].2003,88(5).
- [2]Stillman IE,Epstein FH,Sellke FW,etc.Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia.[J].2003,111(5).
- [3]乐杰.妇产科学[M].2004.