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Evaluation of neoadjuvant chemotherapy for locally advanced cervical cancinoma
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 2
- DOI:
- 10.3760/j.issn:0529-567X.2006.02.007
- Key Word:
- 宫颈肿瘤;化学疗法,辅助;预后
Abstract： 目的探讨局部晚期宫颈癌新辅助化疗的疗效及影响近期疗效的相关因素,以及对患者长期生存的影响.方法收集行新辅助化疗的Ⅰb2～Ⅱb期局部晚期宫颈癌患者64例,分析其化疗后的近期疗效及长期生存率,采用多元线性回归法分析影响化疗近期疗效的相关因素.结果新辅助化疗的近期总有效率为80%(51/64).化疗患者的近期疗效与病理类型有关,鳞癌患者的有效率(82%)明显高于腺癌(6/9,P<0.05);而与其他因素无关(P>0.05).化疗有效者手术后盆腔淋巴结阳性率为8%(4/51),宫旁血管癌栓阳性率为2%(1/51),均明显低于化疗无效者(分别为3/6、2/6;P<0.05).新辅助化疗后患者的总5年生存率为89%,其中化疗有效者5年生存率为100%,明显高于化疗无效者的46%(P<0.05).新辅助化疗有效者3、5年无瘤生存率分别为95%、83%,化疗无效者分别为33%、0,两者分别比较,差异均有统计学意义(P<0.05﹚.结论局部晚期宫颈癌新辅助化疗的近期疗效与病理类型有关,对化疗有效者应选择手术,可提高长期生存率.
- [1]王平,彭芝兰,张家文,等.子宫颈癌新辅助化疗中不同化疗途径的疗效比较[J].2005,(4).
- [2]曹泽毅.子宫颈癌治疗的变迁和思考[J].2004,(3).
- [3]Alfonso Dueñas-González,Lesbia Rivera,Aida Mota,etc.The Advantages of Concurrent Chemoradiation After Neoadjuvant Chemotherapy for Locally Advanced Cervical Carcinoma[J].2002,33(2).
- [4]Benedetti-Panici Pierluigi,Greggi Stefano,Colombo Alessandro,etc.Neoadjuvant chemotherapy and radical surgery versus exclusive radiotherapy in locally advanced squamous cell cervical cancer: results from the Italian multicenter randomized study.[J].2002,20(1).
- [5]Takeshima N,Hirai Y,Nishida H,etc.A randomized study of primary bleomycin, vincristine, mitomycin and cisplatin (BOMP) chemotherapy followed by radiotherapy versus radiotherapy alone in stage IIIB and IVA squamous cell carcinoma of the cervix.[J].2003,23(3C).