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Study of the impact of candidate genes on bone mineral density in postmenopausal women
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 12
- DOI:
- 10.3760/j.issn:0529-567X.2005.12.004
- Key Word:
- 绝经后期;骨密度;骨质疏松,绝经后;糖蛋白类;多态现象(遗传学)
Abstract： 目的探讨有关候选基因对绝经后妇女骨密度变化的影响.方法对205例绝经后妇女,应用双能X线骨密度仪测定腰椎和股骨颈骨密度.采用PCR测序法,检测护骨素基因多态性;采用PCR -限制性片段长度多态性方法,检测甲状旁腺激素、降钙素受体、骨钙素及瘦素受体基因多态性;采用PCR-琼脂糖凝胶电泳法,检测瘦素基因多态性.结果在护骨素基因第1外显子中,发现1个G-1181C单核苷酸多态性.在校正年龄及体重指数对骨密度的影响后,携带护骨素基因CC型及甲状旁腺激素基因bb型妇女的腰椎骨密度较高,分别为(1.042±0.142) g/cm2及(1.196±0.133)g/cm2.降钙素受体、骨钙素、瘦素及瘦素受体基因与骨密度之间无相关关系.经多元逐步回归分析,护骨素、甲状旁腺激素及骨钙素基因与腰椎骨密度变异有关,甲状旁腺激素基因与股骨颈骨密度的变异有关.结论护骨素及甲状旁腺激素基因与绝经后妇女骨量变异有一定关系,降钙素受体、骨钙素、瘦素及瘦素受体基因与绝经后妇女骨密度变异无关.护骨素基因可能是绝经后妇女发生骨量减少的遗传性标记.
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