You Position: Home > Paper
Study of bone mineral density in complete androgen insensitivity syndrome patients
( views:349, downloads:36 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 12
- DOI:
- 10.3760/j.issn:0529-567X.2005.12.003
- Key Word:
- 雄激素迟钝综合征;骨密度;雌激素类;雄激素类
Abstract： 目的探讨完全型雄激素不敏感综合征(CAIS)患者的骨密度特点及性腺切除前后骨密度的变化. 方法回顾性分析北京协和医院28年收治的14例CAIS患者性腺切除术前后的骨密度特征,采用双能X线骨密度仪测定患者的腰椎和股骨颈骨密度,并与中国正常男性和女性的骨密度进行比较和分析. 结果术前10例行骨密度检查的患者中,6例腰椎2～4 骨密度为(0.92±0.08) g/cm2,正常男性为(1.17±0.15) g/cm2,正常女性为(1.17±0.10) g/cm2,与正常男、女性分别比较,差异均有统计学意义(P<0.01);5例股骨颈骨密度为(0.89±0.12) g/cm2,正常男性为(1.06±0.17)g/cm2,正常女性为(0.97±0.14)g/cm2,与正常男、女性分别比较,差异均有统计学意义(P<0.05).术后7例进行过12次骨密度检查,腰椎2～4 骨密度为(0.95±0.06) g/cm2 ,与正常男、女性分别比较,差异均有统计学意义(P<0.01);股骨颈骨密度为(0.91±0.08) g/cm2,与正常男、女性分别比较,差异均有统计学意义(P<0.01,P<0.05).结论 CAIS患者的骨密度均有不同程度的下降,尤其是腰椎,提示雌激素和雄激素在骨量的获得和维持中起重要作用.
- [1]R.M. Francis,M. Peacock,J.E. Aaron,etc.Osteoporosis in hypogonadal men: Role of decreased plasma 1,25-dihydroxyvitamin D, calcium malabsorption, and low bone formation[J].1986,7(4).
- [2]Frank GR.Role of estrogen and androgen in pubertal skeletal physiology.[J].2003,41(3).
- [3]K, Limpaphayom,N, Taechakraichana,M, Poshyachinda,etc.Bone changes in postmenopausal Thai women with or without hormonal replacement therapy.[J].1995,78.
- [4]M. Takeuchi,H. Kakushi,M. Tohkin.Androgens Directly Stimulate Mineralization and Increase Androgen Receptors in Human Osteoblast-like Osteosarcoma Cells[J].1994,204(2).
- [5]余卫,秦明伟,徐苓.正常人股骨近端骨密度变化（附445例DXA测量分析）[J].1998,(1).
- [6]B L, Drinkwater,K, Nilson,C H, Chesnut,etc.Bone mineral content of amenorrheic and eumenorrheic athletes.[J].1984,311.
- [7]M.Muñoz-Torres,E.Jódar,M.Quesada,etc.Bone mass in androgen-insensitivity syndrome: Response to hormonal replacement therapy[J].1995,57(2).
- [8]Morishima A,Grumbach M M,Simpson E R,etc.Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens.[J].1995.
- [9]E P, Smith,J, Boyd,G R, Frank,etc.Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man.[J].1994,331(16).
- [10]H, Mizunuma,M, Soda,H, Okano,etc.Changes in bone mineral density after orchidectomy and hormone replacement therapy in individuals with androgen insensitivity syndrome.[J].1998,13.
- [11]Shane E,Favus M,Quigley CA,etc.The contribution of testosterone to skeletal development and maintenance: lessons from the androgen insensitivity syndrome.[J].2000,85(3).
- [12]Bertelloni, Silvano,Baroncelli, Giampiero I.,Federico, Giovanni,etc.Altered Bone Mineral Density in Patients with Complete Androgen Insensitivity Syndrome.[J].1998,50(6).
- [13]田秦杰,黄尚志,葛秦生.雄激素受体异常与雄激素不敏感综合征[J].1996,(2).