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Combination of external beam radiotherapy and 252Cf neutron intracavitary brachytherapy for cervical cancer
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 4
- DOI:
- 10.3760/j.issn:0529-567X.2005.04.003
- Key Word:
- 锎;中子;宫颈肿瘤;近距离放射疗法
Abstract： 目的 观察252Cf腔内后装加盆腔外照射治疗宫颈癌的疗效以及晚期并发症的发生情况,并对治疗方案进行总结.方法 选择 77例未接受过任何治疗的临床分期为Ⅱa～Ⅳa期的宫颈癌患者作为研究对象,其中Ⅱa期 13例,Ⅱb期 32例,Ⅲa期 18例,Ⅲb期10 例,Ⅳa期4例.治疗方案:252Cf 中子腔内后装治疗,宫旁A点剂量为8～11 Gy/ 次,1次/周,共进行4～5次,使宫旁A点累积剂量达36～45 Gy;该治疗过程中,间歇穿插前后对穿野全盆腔外照射200 cGy/次,4次/周;外照射20～36 Gy后,盆腔野中央屏蔽挡铅4 cm,继续四野外照射200 cGy/次,4次/周,使盆腔外照射总剂量达到45～50 Gy左右.总疗程约需5～6周.结果 77例患者随访3年,3年局部控制率为94%(72/77);3年总生存率为 82%(63/77),其中临床分期Ⅱa期为 85%(11/13),Ⅱb期为 94%(30/32),Ⅲa期为 78%(14/18),Ⅲb期为 70%(7/10),Ⅳa期为 1/4.放射性膀胱炎发生率为3%,放射性直肠炎发生率为5%.结论 252Cf中子腔内后装加盆腔外照射治疗宫颈癌, 患者能较好耐受,且其Ⅱ、Ⅲ期患者的3年生存率较高而并发症发生率较低,具有较好的应用前景.
- [1]罗刚,郑成位,单锦露,等.252 锎中子腔内后装治疗子宫颈癌的临床观察[J].2001,(12).
- [2]王颖,万跃,孙世良.124例宫颈癌放疗后的放射性直肠损伤分析[J].2003,(1).
- [3]周陈华,吕伟超,陈华津,等.192 Ir腔内加体外放射治疗宫颈癌118例分析[J].2002,(4).
- [4]李爱玲,孙建衡,张蓉.子宫颈癌放射治疗512例临床报告[J].2000,(5).
- [5]Y, Maruyama,J R, van Nagell,J, Yoneda,etc.A review of californium-252 neutron brachytherapy for cervical cancer.[J].1991,68(6).
- [6]Y, Maruyama,W, Muir.Human cervical cancer clearance after 252Cf neutron brachytherapy versus conventional photon brachytherapy.[J].1984,7.
- [7]Maruyama Y.,Van Nagell J. R.,Yoneda J.,etc.Schedule in Cf-252 Neutron Brachytherapy[J].1993.
- [8]Y, Maruyama,J M, Feola,J, Wierzbicki,etc.Clinical study of relative biological effectiveness for cervical carcinoma treated by 252Cf neutrons and assessed by histological tumour eradication.[J].1990,63.
- [9]Y, Maruyama,J M, Feola,J, Wierzbicki.Study of biological effects of varying mixtures of Cf-252 and gamma radiation on the acute radiation syndromes: relevance to clinical radiotherapy of radioresistant cancer.[J].1993,27.
- [10]Toita T,Maehama T,Ogawa K,etc.Combination external beam radiotherapy and high-dose-rate intracavitary brachytherapy for uterine cervical cancer: analysis of dose and fractionation schedule.[J].2003,56(5).
- [11]Y, Maruyama,J M, Feola,D, Tai,etc.Californium Cf-252 for pelvic radiotherapy.[J].1978,35.
- [12]Y, Maruyama,J, Mesina,M, Yudelev,etc.New understanding from Cf brachytherapy trials and considerations for neutron therapy of bulky gyn carcinoma for future.[J].1994,170.