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Maternal serum tumor necrosis factor-α concentration and correlation with insulin resistance in gestational diabetes

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
Issue:
11
DOI:
10.3760/j.issn:0529-567X.2004.11.005
Key Word:
肿瘤坏死因子;糖尿病,妊娠;胰岛素抗药性

Abstract: 目的探讨妊娠期糖尿病孕妇血清肿瘤坏死因子α(TNF-α)水平变化与胰岛素抵抗的关系.方法采用酶联免疫吸附试验测定42例妊娠期糖尿病孕妇(GDM组)、40例正常妊娠晚期孕妇(正常妊娠组)空腹血清TNF-α水平;同时测定两组孕妇空腹血糖、C肽、胰岛素、糖化血红蛋白(HbA1c)水平.并且根据公式计算两组孕妇的胰岛素敏感指数(ISI),以评价胰岛素抵抗程度.结果(1)GDM组孕妇空腹血清TNF-α水平为(5.2±1.6)ng/L,正常妊娠组孕妇为(4.5±0.5)ng/L,两组比较,差异有极显著性(P<0.01);GDM组孕妇ISI为-4.3±0.4,正常妊娠组为-3.8±0.3,两组比较,差异有极显著性(P<0.01).(2)GDM组孕妇空腹血糖、胰岛素、C肽水平分别为(5.5±0.7)mmol/L、(13.4±3.8)mU/L、(1.6±0.4)nmol/L,正常妊娠组孕妇空腹血糖、胰岛素、C肽水平分别为(4.9±0.4)mmol/L、(9.3±2.5)mU/L、(1.2±0.3)nmol,两组比较,差异有极显著性(P<0.01);GDM组孕妇HbA1c为(5.6±0.5)%,正常妊娠组孕妇为(5.3±0.5)%,两组比较,差异有显著性(P<0.05).(3)GDM组孕妇空腹血清TNF-α水平与ISI呈显著负相关(r=-0.703, P<0.01),分别与空腹血糖、C肽、HbA1c呈显著正相关(r=0.512、0.629、0.386,P<0.01或P<0.05),与胰岛素无相关性.正常妊娠组孕妇空腹血清TNF-α水平与ISI呈负相关(r=-0.390 P<0.05),但相关性显著小于GDM组,与胰岛素、C肽、血糖及HbA1c无相关性.结论 GDM组孕妇空腹血清TNF-α水平明显升高,且与ISI呈显著负相关,提示GDM孕妇TNF-α参与了胰岛素抵抗.

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