You Position: Home > Paper
Study on estrogen receptor around levator ani muscle for female stress urinary incontinence
( views:47, downloads:197 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 10
- DOI:
- 10.3760/j.issn:0529-567X.2004.10.003
- Key Word:
- 尿失禁,压力性;骨盆底;受体,雌激素
Abstract： 目的探讨绝经后压力性尿失禁(SUI)患者盆底支持结构雌激素受体(ER)与 SUI发生的关系.方法采用免疫组化方法,测定14例SUI患者(SUI组)、7例盆底器官膨出(POP)患者(POP组) 肛提肌及其周围组织中ER阳性率,并选择同期10例非卵巢功能性肿瘤和宫颈病变患者作为对照 (对照组).结果 3组患者肛提肌及其周围组织中,ER阳性率均不高,仅为6.7%.ER细胞核染色阳性的细胞为平滑肌细胞、结缔组织细胞及小神经细胞.肛提肌及其周围组织中,SUI组的结缔组织、平滑肌及小神经细胞的ER阳性率分别为1.1%、2.8%、2.7%,POP组分别为4.1%、9.5%、11.6%,对照组分别为1.4%、4.7%、5.7%.SUI组与对照组比较,差异有极显著性(P<0.01);SUI组与POP组比较,差异也有极显著性(P<0.01).结论绝经后SUI患者的盆底支持结构的退行性病变与雌激素受体水平低下有关;提示POP患者的肛提肌及其周围组织的ER减少,易发生SUI.
- [1]H D, Methfessel,H, Richter,E, Seliger,etc.[Estrogen and progesterone receptors in mesenchymal structures of the female urogenital tract].[J].1989,111(8).
- [2]S, Mosselman,J, Polman,R, Dijkema.ER beta: identification and characterization of a novel human estrogen receptor.[J].1996,392.
- [3]Abrams P,Jackson S,Brookes S,etc.The effect of oestrogen supplementation on post-menopausal urinary stress incontinence: a double-blind placebo-controlled trial.[J].1999,106(7).
- [4]P, Smith,G, Heimer,A, Norgren,etc.Localization of steroid hormone receptors in the pelvic muscles.[J].1993,50.
- [5]E, Samuelsson,A, Victor,K, Sv?rdsudd.Determinants of urinary incontinence in a population of young and middle-aged women.[J].2000,79(3).
- [6]Grady D,Vittinghoff E,Applegate W,etc.Postmenopausal hormones and incontinence: the Heart and Estrogen/Progestin Replacement Study.[J].2001,97(1).
- [7]P, Smith,G, Heimer,A, Norgren,etc.Steroid hormone receptors in pelvic muscles and ligaments in women.[J].1990,30.
- [8]P, Copas,A, Bukovsky,B, Asbury,etc.Estrogen, progesterone, and androgen receptor expression in levator ani muscle and fascia.[J].2001,10(8).