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Clinical application of simplified gonadotropin releasing hormone stimulating test in management of female isosexual precocious puberty
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 6
- DOI:
- 10.3760/j.issn:0529-567X.2004.06.005
- Key Word:
- 女(雌)性;青春期,早熟;促性腺素释放激素
Abstract： 目的探讨简化促性腺激素释放激素(GnRH)兴奋试验用于女性同性性早熟症发病原因的诊断及指导治疗的价值.方法对42例女性同性性早熟患者施行简化GnRH兴奋试验,其中38例患者平均随访26(3～78)个月,观察患者的临床表现及病情发展情况.结果 42例患者对GnRH兴奋试验反应分为黄体生成激素(LH)优势型、卵泡刺激素(FSH)优势型及无反应型3类.其中LH优势型14例(33%,14/42), 包括下丘脑错构瘤1例、特发性性早熟13例;14例中生长过速或骨成熟过早各10例.FSH优势型13例(31%,13/42),包括生长过速2例、骨成熟过早1例.无反应型15例(36%,15/42),8例为外周性性早熟症, 包括卵巢颗粒泡膜瘤1例、自主性功能性卵巢滤泡囊肿2例、McCune-Albright综合征2例、外源性性早熟症3例;15例中生长过速4例、骨成熟过早5例.FSH优势型13例及无反应型的其余7例,未发现明确的发病原因, 考虑为一过性性早熟症或乳房早发育.结论简化GnRH兴奋试验有助于女性同性性早熟症发病原因的诊断,及客观判断下丘脑-垂体-卵巢轴是否被激活,较临床指标更为可靠.
- [1]Reynaud R,Czernichow P,Leger J.Do all girls with apparent idiopathic precocious puberty require gonadotropin-releasing hormone agonist treatment?[J].2000,137(6).
- [2]Thibaud E,Rodriguez Macias-KA,Duflos C,etc.Follow up of precocious pseudopuberty associated with isolated ovarian follicular cysts.[J].1999,81(1).
- [3]Barnes KM,Feuillan PP,Klein KO,etc.Increased final height in precocious puberty after long-term treatment with LHRH agonists: the National Institutes of Health experience.[J].2001,86(10).
- [4]A. Cavallo,G. E. Richards,S. Busey,etc.A simplified gonadotrophin-releasing hormone test for precocious puberty[J].1995,42(6).
- [5]K E, Oerter,M M, Uriarte,S R, Rose,etc.Gonadotropin secretory dynamics during puberty in normal girls and boys.[J].1990,71.
- [6]史轶蘩.协和内分泌与代谢学[M].1999.