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Efficacy and side effects of methotrexate in the treatment of ectopic pregnancy
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 12
- DOI:
- 10.3760/j.issn:0529-567X.2003.12.009
- Key Word:
- 妊娠,输卵管;甲氨蝶呤
Abstract： 目的探讨甲氨蝶呤(MTX)治疗输卵管妊娠的最佳剂量及给药途径.方法回顾性分析648例首选MTX治疗的未破裂输卵管妊娠,根据不同剂量及给药途径分为6组:MTX 100 mg单剂量静脉推注(组1); MTX 100 mg单剂量静脉推注,次日应用四氢叶酸(组2);MTX 100 mg分5 d静脉推注(组3);MTX 100 mg 分5 d肌内注射(组4);MTX 75 mg单剂量静脉推注(组5);MTX 75 mg单剂量肌内注射(组6).比较6组的重复给药率、成功率及副反应情况.结果 (1) 各组重复给药率、成功率比较,差异无显著性(P>0.05),总成功率为88.1%,重复给药率为23.1%.(2) 肝丙氨酸转氨酶异常发生率,组1至组6分别为10.3%、8.3%、64.3%、69.1%、8.7%、31.0%.组1、组2、组5低于其他各组,各组比较,差异均无显著性(P均<0.05).(3)白细胞下降、口腔溃疡及呕吐发生率,各组均较低,各组比较,差异无显著性(P>0.05).结论 MTX相同剂量、不同给药途径治疗输卵管妊娠的疗效相似;75 mg MTX单剂量静脉推注的副反应发生率较低,在输卵管妊娠保守治疗时可作为首选方案.
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