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Thyroid functional changes of normal human fetus and newborns
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 9
- DOI:
- 10.3760/j.issn:0529-567X.2003.09.004
- Key Word:
- 胎儿;婴儿,新生;甲状腺激素类
Abstract： 目的探讨不同胎龄的正常胎儿及新生儿甲状腺激素水平变化及意义.方法对可疑有遗传、内分泌、感染、代谢性疾病的孕16～36周胎儿71例(观察组),在B超引导下,行脐静脉穿刺,孕妇甲状腺功能均正常.选择同期孕足月自然分娩的140例新生儿脐带血为对照组.测定两组甲状腺激素水平及甲状腺功能.并对孕28周前后的胎儿甲状腺功能、胎儿与新生儿甲状腺激素水平进行比较.结果自孕16周起,胎儿甲状腺激素均可检测到,并随孕周增加而增加;游离甲状腺素(FT4)在孕16周时为(5.8±2.6)pmol/L,接近正常成人甲状腺素水平,以后持续上升;胎儿甲状腺素(T4)、三碘甲状腺原氨酸(T3)、FT4在28孕周后较28周前显著升高,即分别由(2.8±1.8)nmol/L、(37.2±27.2)nmol/L、(10.6±3.1) pmol/L增至(5.8±2.6)nmol/L、(55.9±33.3)nmol/L(13.0±4.5)pmol/L.孕20周时,胎儿促甲状腺激素(TSH)水平达到正常成人上限,为(4.6±1.4)mU/L,以后持续上升,分娩期达高峰,为(9.2±6.7)mU/L.而T3及游离三碘甲状腺原氨酸(FT3)在整个孕期始终处于较低水平.结论胎儿甲状腺激素水平随孕周增长而升高.孕中期以后,胎儿T4、FT4及TSH,可作为判断胎儿甲状腺功能的主要指标.
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