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Expression of leptin and long form of leptin receptors messenger ribonucleic acid and protein in endometrium of patients with polycystic ovary syndrome
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 7
- DOI:
- 10.3760/j.issn:0529-567X.2003.07.005
- Key Word:
- 多囊卵巢综合征;子宫内膜;瘦素;载体蛋白质类
Abstract： 目的探讨瘦素(leptin)和瘦素长受体(Ob-RL) mRNA及蛋白在多囊卵巢综合征(PCOS)患者着床期子宫内膜的表达及意义.方法应用免疫组织化学技术及原位杂交技术,分别对15例正常妇女(对照组)、14例无排卵PCOS患者(PCOS组)促排卵治疗后着床期子宫内膜的leptin、Ob-RL mRNA及蛋白进行测定.结果对照组中,子宫内膜10例呈分泌期中期改变,5例呈分泌期早期改变.PCOS组中,子宫内膜3例呈分泌期中期改变,6例呈分泌期早期改变,1例呈增殖期改变,4例呈增殖期并分泌期早期改变;子宫内膜发育不良发生率79%(11/14),与对照组比较,差异有显著性(P<0.05).Ob-RL mRNA和蛋白在 PCOS患者子宫内膜腺体呈阴性到强阳性表达,但多呈弱阳性和阳性表达,对照组则呈弱阳性到强阳性表达,两组比较,差异有显著性(P<0.05);leptin mRNA和蛋白在PCOS患者子宫内膜的表达与对照组相似,两组比较,差异无显著性(P>0.05).结论促排卵周期中,Ob-RL在PCOS患者着床期子宫内膜腺体表达减弱,可能与PCOS患者妊娠率低有关.
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