Study on the relationship between endogenous opioid peptides and fetal distress
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 12
- DOI:
- 10.3760/j.issn:0529-567X.2002.12.005
- Key Word:
- 胎儿窘迫;阿片样肽类
Abstract： 目的探讨内源性阿片肽与胎儿窘迫发生的关系.方法采用放射免疫法测定40例正常妊娠妇女(正常妊娠组)及43例胎儿窘迫孕妇(胎儿窘迫组)静脉血及其新生儿脐血中阿片肽(β-内啡肽、强啡肽A1-13和亮啡肽)的水平,胎儿窘迫组孕妇同时行新生儿脐动脉血血气分析.结果 (1)胎儿窘迫组脐血中β-内啡肽、强啡肽A1-13和亮啡肽的水平分别为(453±68) ng/L、(242±33) ng/L及(498±68) ng/L;正常妊娠组分别为(251±39) ng/L、(103±22) ng/L及(322±40) ng/L.与正常妊娠组比较,胎儿窘迫组脐血中3种阿片肽水平均显著升高(P<0.05).(2)胎儿窘迫组脐血血气分析结果:pH为(7.0±0.1),PO2为(1.7±0.6) kPa, PCO2为(8.9±0.7) kPa;其中β-内啡肽水平与脐血pH、PO2呈显著负相关[相关系数(r)为-0.418及-0.437,P<0.01],与PCO2呈显著正相关(r=0.442,P<0.01);强啡肽A1-13水平与脐血pH及PO2呈负相关(r为-0.337及-0.383,P<0.05),与PCO2呈正相关(r=0.346,P<0.05).(3)胎儿窘迫组孕妇血中β-内啡肽、强啡肽A1-13和亮啡肽水平分别为(40±13) ng/L、(64±16) ng/L及(219±40) ng/L;正常妊娠组分别为(37±9) ng/L、(59±15) ng/L及(199±37) ng/L;两组间3种阿片肽水平比较,差异均无显著性(P>0.05).结论内源性阿片肽参与了胎儿窘迫的病理过程,与胎儿窘迫的发生、发展密切相关.
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