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Relationship between human leukocyte antigen-DRB1 allele gene polymorphism and intrahepatic cholestasis of pregnancy
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 9
- DOI:
- 10.3760/j.issn:0529-567X.2002.09.003
- Key Word:
- 妊娠并发症;胆汁郁积,肝内;疾病遗传易感性;HLA-DR抗原;等位基因;多态现象(遗传学)
Abstract： 目的探讨人类白细胞抗原(HLA)-DRB1基因多态性与妊娠期肝内胆汁淤积症(ICP)的关系.方法采用聚合酶链反应序列寡核苷酸(PCR-SSO)探针杂交法对42例ICP患者(ICP组)和56例正常孕妇(对照组)进行HLA-DRB1等位基因分型,比较其基因频率及其与临床表型之间的关系.同时对ICP组孕妇的肝功能及甘胆酸盐水平进行检测.结果两组孕妇中,HLA-DR9、DR12、DR4基因频率均较高.ICP组孕妇中共检出14例HLA-DR6等位基因,对照组仅检出4例HLA-DR6等位基因.ICP组中HLA-DR6等位基因频率为16.7%,对照组为3.6%,两组比较,差异有极显著性(P<0.01).其余各等位基因频率两组比较,差异均无显著性(P>0.05).未发现ICP组孕妇HLA-DR6基因与肝功能及甘胆酸盐水平有相关关系.结论 ICP患者HLA-DR6基因可能是ICP发病的易感基因之一.
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