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A study of rubella virus infection during pregnancy
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 7
- DOI:
- 10.3760/j.issn:0529-567X.2002.07.003
- Key Word:
- 妊娠并发症,感染性;风疹病毒感染
Abstract： 目的探讨妊娠期妇女风疹病毒的感染状况及对胎儿的影响.方法应用酶联免疫吸附方法对1 471例孕妇进行风疹病毒IgG、IgM抗体检测;对其中3例引产和死产的胎儿组织及胎盘行组织切片和电子显微镜检查,并用逆转录-聚合酶链反应(RT-PCR)技术检测风疹病毒核酸.结果 76.1%(1 119/1 471)的孕妇风疹病毒IgG阳性;7.4%(109/1 471)的孕妇风疹病毒IgM阳性;14.1%(208/1 471)的孕妇风疹病毒IgG、IgM阴性;2.4%(35/1 471)的孕妇风疹病毒IgG、IgM阳性.7例跟踪随访孕妇中,2例出现死胎,1例要求引产;1例引产胎儿的心肌组织细胞和2例死胎的心肌、肝、脑组织细胞及胎盘中均发现风疹病毒颗粒,并经RT-PCR检测到风疹病毒核酸.结论妊娠期7.4%的孕妇可感染风疹病毒,并导致胎儿宫内感染,造成胎儿不同程度的损伤或严重的先天性风疹综合征.
- [1]林琳华,任景慧,姚秋璇,等.妊娠合并风疹病毒重复感染一例[J].2001,(1).
- [2]杜季梅,郑飞云,谭映霞,等.孕妇风疹病毒IgG、IgM检测及意义[J].2001,(3).
- [3]Mitsuyo Tanemura,Kaoru Suzumori,Yoshiaki Yagami,etc.Diagnosis of fetal rubella infection with reverse transcription and nested polymerase chain reaction: A study of 34 cases diagnosed in fetuses[J].1996,174(2).
- [4]Parkman, Paul D..Making Vaccination Policy: The Experience with Rubella.[J].1999,28.
- [5]耿贯一.流行病学[M].1996.
- [6]Yosef L,Frank T,Barnea B,etc.Clinical rubella reinfection during pregnancy in a previously vaccinated woman.[J].2000,41(2).
- [7]戴斌,刘凤喜.妊娠早期妇女原发风疹感染率的研究[J].1992,026 (4).
- [8]金奇.医学分子病毒学[M].2001.