You Position: Home > Paper
Relationship between human parvovirus B19 infection and spontaneous abortion and congenital heart disease in China
( views:401, downloads:86 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 6
- DOI:
- 10.3760/j.issn:0529-567X.2002.06.002
- Key Word:
- 人细小病毒B19;聚合酶链反应;自然流产;先天性心脏病
Abstract： 目的探讨胎儿人细小病毒B19 (HPV B19)感染与孕妇自然流产、胎儿先天性畸形的关系.方法 (1)以巢式聚合酶链反应法检测182例自然流产的胚胎组织标本(自然流产组)中HPV B19 DNA,以40例正常的胚胎组织标本为自然流产对照组.(2)以巢式聚合酶链反应法检测66例先天性心脏病患儿的心肌组织标本(心肌组)HPV B19 DNA,同时收集37例先天性心脏病患儿的外周血与之配对行HPV B19-IgM的酶联免疫吸附试验检测;以30例非先天性心脏病患儿的心肌标本为心肌对照组.结果 (1)自然流产组中HPV B19 DNA阳性率为25.8%(47/182),而自然流产对照组阳性率为5.0%(2/40).(2)心肌组中HPV B19 DNA阳性率为18.2%(12/66),而心肌对照组阳性率为0%(0/30).(3)配对标本中心肌HPV B19 DNA阳性7例,其外周血中HPV B19-IgM全部阴性.结论 HPV B19宫内感染可能与自然流产和先天性心脏病的发生有一定关系.
- [1]Jensen L,Heegaard ED,Hornsleth A,etc.The role of parvovirus B19 infection in childhood acute lymphoblastic leukemia.[J].1999,16(4).
- [2]许东亮,张国成,王荣平.套式聚合酶链反应检测自然流产组织中人细小病毒B19[J].1998,(2).
- [3]Sabella C,Goldfarb J.Parvovirus B19 infections.[J].1999,60(5).
- [4]K E, Brown,J R, Hibbs,G, Gallinella,etc.Resistance to parvovirus B19 infection due to lack of virus receptor (erythrocyte P antigen).[J].1994,330(17).