Comparative study on two different dosages of conjugated equine estrogen continuously combined with medroxyprogesterone in prevention of postmenopausal osteoporosis
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 5
- DOI:
- 10.3760/j.issn:0529-567X.2002.05.004
- Key Word:
- 骨质疏松,绝经后;激素替代疗法;绝经前期;骨密度;雌激素类;子宫内膜
Abstract： 目的探讨两种剂量结合雌激素(CEE)对绝经早期妇女骨丢失的影响及副作用.方法将236例绝经妇女分为3组,A组每日口服CEE 0.625 mg+醋甲羟孕酮(MPA)2 mg+钙剂(Ca-D)1片(含元素钙600 mg);B组每日口服CEE 0.3 mg+MPA 2 mg+Ca-D 1片;C组每日仅服Ca-D 1片,连续用药2年.于治疗前、治疗12及24个月测量第2～4腰椎(L2～4)的骨密度(BMD),记录每月阴道出血情况.结果 A组治疗前、治疗12及24个月,L2～4 BMD分别为(1 062±141)、(1 086±145)及(1 101±134) mg/cm2,治疗前后比较,差异均有极显著性(P<0.001);B组分别为(1 081±135)、(1 111±168)及(1 090±150) mg/cm2,治疗12个月时与治疗前比较,差异有显著性(P<0.05),治疗24个月时与治疗前比较,差异无显著性(P>0.05);C组分别为(1 070±119)、(1 065±134)及(1 053±130) mg/cm2,治疗前后比较,差异均无显著性(P>0.05).治疗前后BMD的变化,A与C组、B与C组之间差异均有显著性(P<0.001,<0.05);A与B组治疗12个月时的BMD比较,差异无显著性(P>0.05),24个月时比较,差异有极显著性(P<0.01).各组子宫内膜均无不典型增生.A、B组出血率,治疗12个月时分别为43%及12%,24个月时分别为34%及8%.结论每日口服CEE 0.625 mg或0.3 mg,均可有效预防绝经早期的骨丢失,CEE 0.625 mg剂量预防骨丢失效果及阴道出血率均高于0.3 mg.
- [1]D T, Felson,Y, Zhang,M T, Hannan,etc.The effect of postmenopausal estrogen therapy on bone density in elderly women.[J].1993,329(16).
- [2]C, Christiansen.Hormone replacement therapy and osteoporosis.[J].1996,23 Suppl.
- [3]Merete Sanvig Christensen,Claus Hagen,Claus Christiansen,etc.Dose-response evaluation of cyclic estrogen/gestagen in postmenopausal women: Placebo-controlled trial of its gynecologic and metabolic actions[J].1982,144(8).
- [4]Prestwood K M,Pilbeam C C,Burleson J A,etc.The short-term effects of conjugated estrogen on bone turnover in older women.[J].1994.
- [5]Mizunuma, H.,Okano, H.,Soda, M.,etc.Prevention of postmenopausal bone loss with minimal uterine bleeding using low dose continuous estrogen/progestin therapy: a 2-year prospective study[J].1997,27(1).