Effects of fetal anoxia and acidosis on superoxide dismutase
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 4
- DOI:
- 10.3760/j.issn:0529-567X.2002.04.005
- Key Word:
- 胎儿窘迫;酸中毒,呼吸性;胎儿缺氧;超氧化物歧化酶
Abstract： 目的探讨胎儿窘迫状态下缺氧、呼吸性酸中毒和代谢性酸中毒等因素对胎儿抗氧化作用的影响.方法对386例新生儿出生时抽取脐动脉血行血气分析和超氧化物歧化酶(SOD)水平检测,根据脐动脉血气分析结果诊断新生儿有无缺氧、代谢性酸中毒、呼吸性酸中毒及混合性酸中毒;同时根据出生后1分钟Apgar评分,诊断新生儿有无窒息(缺氧).并行多因素方差分析.结果 (1)386例新生儿中,无缺氧及酸中毒者317例,单纯缺氧31例,单纯酸中毒17例,缺氧+酸中毒21例;酸中毒中,呼吸性酸中毒8例,代谢性酸中毒21例,混合性酸中毒9例.(2)SOD水平检测:单纯缺氧者为(118.5±7.1) mmol/L,单纯酸中毒者为(122.0±11.4) mmol/L,缺氧+酸中毒者为(140.0±7.0) mmol/L,无缺氧无酸中毒者为(98.5±2.6) mmol/L;多因素方差分析结果显示,缺氧: F ＝4.999( P <0.05),酸中毒: F =7.025( P <0.01),缺氧+酸中毒: F =0.013( P >0.05).(3)呼吸性酸中毒者的SOD水平为(127.3±18.4) mmol/L,代谢性酸中毒者为(126.0±8.1) mmol/L,混合性酸中毒者为(150.0±10.4) mmol/L;多因素方差分析结果显示,呼吸性酸中毒: F ＝4.404( P <0.05),代谢性酸中毒: F ＝3.965( P <0.05),混合性酸中毒: F =0.015( P >0.05).结论缺氧与酸中毒,混合性酸中毒均能引起机体过氧化反应和抗氧化能力增强;但它们引起细胞损伤的机制可能不同,相互之间只有叠加效应,无协同作用.
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