You Position: Home > Paper
Preliminary study on the role of vascular endothelial growth factor in pathogenesis of ovarian hyperstimulation syndrome
( views:247, downloads:60 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 11
- DOI:
- 10.3760/j.issn:0529-567X.2001.11.004
- Key Word:
- 卵巢过度刺激综合征;淋巴因子;内皮生长因子;病因学
Abstract： 目的通过对卵巢过度刺激综合征(OHSS)患者血管内皮生长因子(VEGF)水平和表达的测定,初步探讨VEGF在OHSS发病机理中的作用.方法采用酶联免疫吸附试验方法对14例中、重度OHSS患者(OHSS组)和同期13例非OHSS患者(对照组)取卵日卵泡液、人绒毛膜促性腺激素(hCG)注射日、胚胎移植(ET)日血清VEGF水平进行测定;采用免疫组织化学方法和逆转录聚合酶链反应技术检测取卵日卵巢黄素化颗粒细胞VEGF及其mRNA的表达.结果 OHSS组和对照组的卵泡液、hCG注射日血清VEGF水平分别为(1 257.2±648.0)与(1 745.1±802.4) ng/L,(250.1±109.5)与(196.7±81.7) ng/L,两组比较,差异无显著性(P>0.05);OHSS组ET日血清VEGF水平及注射hCG后血清VEGF水平变化程度,显著高于对照组[分别为(342.9±158.5)与(222.2±84.6) ng/L,(92.8±106.7)与(25.9±21.8) ng/L,P<0.05].OHSS组取卵日卵巢黄素化颗粒细胞VEGF mRNA的表达,显著高于对照组,VEGF/β肌动蛋白比值分别为1.50±0.60、0.96±0.56(P<0.05).两组取卵日卵巢黄素化颗粒细胞有较活跃的VEGF表达.结论 VEGF在OHSS的发病机理中可能起一定的作用.
- [1]Yoram Abramov,Vivian Barak,Benjamin Nisman,etc.Vascular endothelial growth factor plasma levels correlate to the clinical picture in severe ovarian hyperstimulation syndrome[J].1997,67(2).
- [2]Rina Agrawal,Seang Ling Tan,Sarah Wild,etc.Serum vascular endothelial growth factor concentrations in in vitro fertilization cycles predict the risk of ovarian hyperstimulation syndrome[J].1999,71(2).
- [3]V, Vincenti,C, Cassano,M, Rocchi,etc.Assignment of the vascular endothelial growth factor gene to human chromosome 6p21.3.[J].1996,93.
- [4]Neulen J,Yan Z,Raczek S,etc.Human chorionic gonadotropin-dependent expression of vascular endothelial growth factor\/vascular permeability factor in human granulosa cells: importance in ovarian hyperstimulation syndrome.[J].1995.
- [5]N, Ferrara,W J, Henzel.Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells.[J].1989,161(2).
- [6]H F, Dvorak,J A, Nagy,D, Feng,etc.Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis.[J].1999,237.
- [7]J S, Krasnow,S L, Berga,D S, Guzick,etc.Vascular permeability factor and vascular endothelial growth factor in ovarian hyperstimulation syndrome: a preliminary report.[J].1996,65(3).