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The follow-up of 12 pregnant women with anticoagulation therapy after mechanical heart valve replacement
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 8
- DOI:
- 10.3760/j.issn:0529-567X.2001.08.005
- Key Word:
- 心脏瓣膜,人工;妊娠;华法林;心脏外科手术
Abstract： 目的探讨心脏机械瓣膜置换术后妊娠妇女抗凝治疗的方法,以及抗凝药物对孕妇和胎儿的影响.方法随访12例心脏机械瓣膜置换术后妇女妊娠、分娩期抗凝治疗情况.结果 12例患者整个妊娠期均采用口服抗凝药治疗(除1例曾停服半月外).国产华法林平均用量为(3.14±0.28)mg/d(6例),进口华法林平均用量为(2.71±1.24)mg/d(4例),国产新抗凝(3.14±1.08)mg/d(2例).所有孕妇均无严重出血及栓塞等并发症发生,8例次有一般性出血现象;足月妊娠10例,早产2例,新生儿均无畸形发生,仅1例新生儿出生体重低于正常(2 100 g).结论心脏机械瓣膜置换术后妇女妊娠期间,单一服用较小剂量的华法林(＜5 mg/d)行抗凝治疗对孕妇安全、方便,且无胎儿畸形发生.
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