You Position: Home > Paper
Placental expression of epidermal growth factor receptor in pregnancy induced hypertension
( views:268, downloads:20 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Issue:
- 6
- DOI:
- 10.3760/j.issn:0529-567X.2001.06.005
- Key Word:
- 妊娠并发症,心血管;高血压;受体,表皮生长因子;胎盘;滋养层
Abstract： 目的探讨妊娠高血压综合征(妊高征)患者胎盘滋养细胞表皮生长因子受体(EGFR)的表达及意义。方法采用免疫组织化学法观察30例妊高征患者(妊高征组)胎盘EGFR的表达及其与妊高征病情、胎盘重量及新生儿出生体重的关系, 并与34例正常妊娠妇女(正常妊娠组)比较。结果 EGFR阳性颗粒位于合体滋养细胞的胞膜和胞浆内，少数细胞滋养细胞内也见阳性颗粒。与正常妊娠组比较，妊高征组胎盘EGFR表达显著降低(P<0.05)，轻度、中度、重度妊高征患者胎盘EGFR表达，差异无显著性(P>0.5)；妊高征组胎盘EGFR表达强度与胎盘重量、新生儿出生体重无显著相关性(P值均>0.1)。结论妊高征患者胎盘EGFR表达显著降低，可能与妊高征的发病有关。
- [1]F B, Fromowitz,M V, Viola,S, Chao,etc.Ras P21 Expression in the Progression of Breast Cancer.[J].1987,18(12).
- [2]G A, Dekker,B M, Sibai.Etiology and pathogenesis of preeclampsia: current concepts.[J].1998,179(5).
- [3]K H, Lim,Y, Zhou,M, Janatpour,etc.Human cytotrophoblast differentiation/invasion is abnormal in pre-eclampsia.[J].1997,151.
- [4]Lunell NO,Nisell H,Faxen M,etc.Altered mRNA expression pattern of placental epidermal growth factor receptor (EGFR) in pregnancies complicated by preeclampsia and/or intrauterine growth retardation.[J].1998,15(1).
- [5]E, DiFederico,O, Genbacev,S J, Fisher.Preeclampsia is associated with widespread apoptosis of placental cytotrophoblasts within the uterine wall.[J].1999,155(1).
- [6]乐杰主编.妇产科学 第四版[M].1980.