You Position: Home > Paper

Expression of endometrial leukaemia inhibitory factor gene in patients with unexplained infertility

( views:193, downloads:8 )
Author:
No author available
Journal Title:
CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
Issue:
2
DOI:
10.3760/j.issn:0529-567X.2001.02.005
Key Word:
子宫内膜;淋巴因子;生长抑制物;卵植入;不育,女(雌)性

Abstract: Objective To investigate the expression of endometrial leukaemia inhibitory factor(LIF) gene in patients with unexplained infertility. Methods  By a quantitative reverse transcription-polymerase chain reaction (RT-PCR),the expression of LIF gene on endometrium during mid-luteal phase was detected in 35 unexplained infertility (infertility group) cases and 20 infertile cases due to tubal obstruction or male factor (control group). Results The level of LIF mRNA expression on endometrium during mid-luteal phase in infertility group was 0.448±0.239,significantly lower than those in the control group (1.093±0.761,P<0.01). Conclusions Our findings suggested LIF might play an important role in the process of implantation. The decreased expression of LIF gene might be one of the major causes of unexplained infertility.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn