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Study on association of vascular endothelial growth factor with the pathogenesis of pregnancy induced hypertension

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY
Issue:
2
DOI:
10.3760/j.issn:0529-567X.2001.02.002
Key Word:
妊娠并发症,心血管;高血压;内皮生长因子;淋巴因子

Abstract: Objective To investigate relationship between the vascular endothelial growth factor (VEGF) and the pathogenesis of pregnancy induced hypertension syndrome (PIHs). Methods Twenty-three women with PIHs and twenty normal pregnant women were studied. The levels of VEGF in maternal and umbilical venous serum, placenta and decidual tissue from normal pregnancy and PIHs women were detected by enzyme linked immunosorbent assay (ELISA) and immunohistochemisty. Furthermore, the expression of VEGF mRNA in placenta and decidua was examined by reverse transcriptase polymerase chain reaction (RT-PCR). Results (1) The levels of VEGF in maternal blood were significantly lower in PIHs women than that in normal pregnancies wonen (10.4±3.8) ng/L and (17.0±9.3) ng/L (P<0.01). (2) The average gray of VEGF was determined on sections of placenta and decidua from PIHs or pregnancies women by computer image analysis. The expression of VEGF in placenta and decidua (69.0±8.9) and (55.0±7.3) was decreased significantly in PIHs women than that in normal pregnancies wonen (75.0±9.0) and (60.5±6.4, P<0.05). (3) The transcription levels of the VEGF mRNA in placenta and decidua were increased significantly in PIHs women than those in normal pregnancies women (4.6±3.2 vs 2.8±1.0;6.3±2.9 vs 3.9±1.5,P<0.01). Conclusions These findings suggested that the abnormal expression of VEGF in PIHs occured within the low-stream of genic transcription. It was considered that the abnormal expression of VEGF may play an important role in the pathogenesis of plcental ischemia in PIHs.

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