Determination of serum soluble interleukin-6 receptor and soluble gp130 levels in patient with pregnancy induced hypertension and its significance

( views:174, downloads:0 )
Author:
Li Yali()
WANG Yue()
Qi Lei()
Journal Title:
CHINESE JOURNAL OF OBSTETRICS AND GYMECOLOGY
Issue:
Volume 36, Issue 01, 2001
DOI:
Key Word:

Abstract: Objective To observe the changes of serum soluble interleukin-6 receptor (sIL-6R) and soluble gp130 (sgp130) in patients with pregnancy induced hypertension. Methods Enzyme linked immunosorbent assay (ELISA) was used to determine serum sIL-6R and sgp130 levels in 40 patients with pregnancy induced hypertension (study group), 20 normal non-pregnant women (control group I) and 20 normal pregnant women (control group II). Results In study group, sIL-6R was (196.7±12.9) μg/L and sgp130 was (379.4±79.3) μg/L. In control group I, sIL-6R was (174.8±46.2) μg/L and sgp130 was (273.6±28.3) μg/L. In control group II, sIL-6R was (174.4±48.3) μg/L and sgp130 was (254.4±34.7) μg/L. SIL-6R and sgp 130 were higher in study group than those in control groups with significant difference (P<0.01). In study group, the more severe the patients, the higher the sIL-6R and sgp130 levels. There was significant difference (P<0.01). There was no difference in sIL-6R and sgp130 levels between control groups (P>0.05). Conclusions Serum sIL-6R and sgp130 levels are related to the development of pregnancy induced hypertension.

  • Sibai BM. Immunologic aspects of preeclampsia. Clin Obstet Gynecol, 1991,34:27-34.
  • 王子芬,宋海翔,石少兰,等. 妊高征患者白细胞介素6变化的意义. 中华妇产科杂志,1999,34:220-221.
  • 乐杰,主编. 妇产科学. 第4版. 北京:人民卫生出版社,1996. 113-118.
  • 侯健,王东星,胥军民,主编. 人类细胞因子手册. 上海:同济大学出版社,1996. 139-140
  • Vince GS, Starkey PM. Interleukin-6, tumor necrosis factors and soluble tumor necrosis factor receptors in women with pre-eclampsia. Br J Obstet Gynecol, 1995, 102:20-25.
  • 阴春霞,田永庆,郑莹. 白细胞介素6及其mRNA与妊高征发病的关系. 中华妇产科杂志,1998,33:711-713
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn