Relationship between placenta growth factor and the pathogenesis of pregnancy induced hypertension syndrome

( views:136, downloads:0 )
Author:
LIU Wei()
LIN Qide()
Wang Lidong()
()
Journal Title:
CHINESE JOURNAL OF OBSTETRICS AND GYMECOLOGY
Issue:
Volume 36, Issue 01, 2001
DOI:
Key Word:

Abstract: Objective To determine whether pregnancy induced hypertension syndrome (PIHs) is associated with placenta growth factor (PLGF). Methods PLGF level in the maternal and umbilical venous serum collected from 23 PIHs patients and 20 normotensive controls was measured by enzyme linked immunoassay (ELISA), and expression of PLGF and its mRNA in the placenta and decidua from them was assessed by the immuno-histochemistry and reverse transcriptional-polymerase chain reaction (RT-PCR). Results (1) PLGF levels in the maternal serum from PIHs [(112.7±63.8) μg/L] were significantly lower than those from normal pregnancies [(200.3±140.9) μg/L],(P<0.05), and they were correlated with infant birth weight and placental mass (r=0.4, r=0.6). (2) Expression of PLGF in sycytiotrophoblast and villous mesenchyme and decidua from PIHs significantly decreased respectively (P<0.01, P<0.01, P<0.05), and expression of PLGF in sycytiotrophoblast was associated with the severity of PIHs (P<0.05). (3) The transcription of total PLGF mRNA in the placenta and decidua from PIHs decreased significantly (P<0.05 and P<0.05 respectively). Particularly, the transcription of PLGF-2 mRNA decreased significantly in the placenta from PIHs. Conclusion The abnormal expression of PLGF may play an important role in the pathogenesis of placental ischaemia hypoxia in PIHs.

  • 林其德. 妊高征病因学研究的进展. 中华妇产科杂志, 1997, 32:3-5
  • Cao Y, Ji WR, Qi P, et al. Placenta growth factor: identification and characterization of a novel isoform generated by RNA alternative splicing. Biochem Biophys Res Commun, 1997, 235:493-498
  • Khalig A, Dunk C, Jiang J, et al. Hypoxia down-regulates placenta growth factor, whereas fetal growth restriction up-regulates placenta growth factor expression: molecular evidence for “placenta hyperoxia” in intrauterine growth restrition. Lab Invest, 1999, 79: 151-170
  • 乐杰, 主编. 妇产科学.第4版. 北京:人民卫生出版社, 1996. 115-117
  • Shore VH, Wang TH, Wang CL, et al. Vascular endothelial growth factor, placenta growth factor and their receptors in isolated human trophoblast. Placenta, 1997, 18:657-665
  • 林其德, 潘家骧, 金新娟, 等. 妊高征子宫螺旋形小动脉免疫病理观察. 中华妇产科杂志, 1992, 27:209-211
  • Khalig A, Li XF, Shams M, et al. Localization of placenta growth factor (PLGF) in human term placenta. Growth Factors, 1996, 13:243-250
  • Migdal M, Huppertz B, Tessler S, et al. Neuropilin-1 is a placenta growth factor-2 receptor. J Bio Chem, 1998, 273:272-278
  • Sawano A, Takahashi T, Yamaguchi S, et al. Flt-1 but not KDR/Flk-1 tyrosine kinase is a receptor for placenta growth factor, which is related to vascular endothelial growth factor. Cell Growth Differ, 1996, 7:213-221
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn