Gray matter involvement in patients with multiple sclerosis as shown by magnetic resonance imaging

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Author:
Reshiana Rumzan(Department of Radiology, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China)
CHEN Xuan(Department of Radiology, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China)
LI Yong-mei(Department of Radiology, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China)
Journal Title:
Chinese Medical Journal
Issue:
Volume 125, Issue 13, 2012
DOI:
10.3760/cma.j.issn.0366-6999.2012.13.021
Key Word:
multiple sclerosis;gray matter;magnetic resonance imaging

Abstract: Objective To summarize the main findings seen on conventional and advanced magnetic resonance imaging (MRI)used to assess gray matter (GM) involvement in patients with multiple sclerosis (MS).Data sources The data used in this review were obtained mainly from studies reported in the PubMed database using the terms of multiple sclerosis,gray matter,magnetic resonance imaging.Study selection Relevant literatures on studies of GM involvement in MS patients were identified,retrieved and reviewed.Results MS is the most common chronic,disabling central nervous system disease in young adults.Although traditional thinking has considered MS to be a chronic inflammatory demyelinating condition affecting solely the white matter (WM) of the central nervous system,over the last few years it has been shown that GM pathology is also common and extensive.GM demyelinating lesions can not only be found in the cerebral cortex but also in the deep gray nuclei.Apart from focal demyelinatad lesions,diffuse neuronal loss and atrophy is also present in the GM of MS patients.Conclusions The widespread use of conventional and quantitative MRI based techniques in MS has led to an improved understanding of the mechanisms underlying the inflammatory and neurodegenerative processes of the disease.However,more researches are needed to unravel GM pathology in MS patients,which at present remains enigmatic.

  • 1.Frohman EM,Racke MK,Raine CS.Multiple sclerosis the plaque and its pathogenesis.N Engl Med 2006; 354:942-955.
  • 2.Bo L.The histopathology of grey matter demyelination in multiple sclerosis.Acta Neurol Scand Suppl 2009; 189:51-57.
  • 3.Niepel G,Tench CR,Morgan PS,Evangelon N,Auer DP,Constantinescu CS.Deep gray matter and fatigue in MS:a T1 relaxation time study.J Neurol 2006; 253:896-902.
  • 4.Morgen K,Sammer G,Courtney SM,Wolters T,Melchior H,Blecker CR,et al.Evidence for a direct association between cortical atrophy and cognitive impairment in relapsing-remitting MS.Neuroimage 2006; 30:891-898.
  • 5.Brownell B,Hughes JT.The distribution of plaques in the cerebrum in multiple sclerosis.J Neurol Neurosurg Psychiatry 1962; 25:315-320.
  • 6.B(o) L,Vedeler CA,Nyland H,Trapp BD,M(o)rk SJ.Intracortical multiple sclerosis lesions are not associated with increased lymphocyte infiltration.Mult Scler 2003; 9:323-331.
  • 7.Papadopoulos D,Dukes S,Patel R,Nicholas R,Vora A,Reynolds R.Substantial archaeocortical atrophy and neuronal loss in multiple sclerosis.Brain Pathol 2009; 19:238-253.
  • 8.Ramasamy DP,Benedict RH,Cox JL,Fritz D,Abdelrahman N,Hussein S,et al.Extent of cerebellum,subcortical and cortical atrophy in patients with MS:a case-control study.J Neurol Sci 2009; 282:47-54.
  • 9.Tedeschi G,Dinacci D,Comerci M,Lavorgna L,Savettieri G,Quattrone A,et al.Brain atrophy evolution and lesion load accrual in multiple sclerosis:a 2-year follow-up study.Mult Scler 2009; 15:204-211.
  • 10.Geurts JJ,Pouwels PJ,Uitdehaag BM,Polman CH,Barkhof F,Castelijns JA.Intracortical lesions in multiple sclerosis:improved detection with 3D double inversion-recovery MR imaging.Radiology 2005; 236:254-260.
  • 11.Nelson F,Poonawalla AH,Hou P,Huang F,Wolinsky JS,Narayana PA.Improved identification of intracortical lesions in multiple sclerosis with phase-sensitive inversion recovery in combination with fast double inversion recovery MR imaging.AJNR Am J Neuroradiol 2007; 28:1645-1649.
  • 12.Wang F,Yu C,Li K.Progress on MRI investigation on multiple sclerosis.Chin J Med Imaging Technol (Chin) 2009;25:2132-2134.
  • 13.Chen X,Li Y.Development of multi-modal magnetic resonance imaging in gray matter lesions of multiple sclerosis.Chin J Med Imaging Technol (Chin) 2010; 26:1990-1992.
  • 14.Sastre-Garriga J,Ingle GT,Chard DT,Ramió-Torrentà L,McLean MA,Miller DH,et al.Metabolite changes in normal-appearing gray and white matter are linked with disability in early primary progressive multiple sclerosis.Arch Neurol 2005; 62:569-573.
  • 15.Geurts JJ,Reuling IE,Vrenken H,Uitdehaag BM,Polman CH,Castelijns JA,et al.MR spectroscopic evidence for thalamic and hippocampal,but not cortical,damage in multiple sclerosis.Magn Reson Med 2006; 55:478-483.
  • 16.Srinivasan R,Ratiney H,Hammond-Rosenbluth KE,Pelletier D,Nelson SJ.MR spectroscopic imaging of glutathione in the white and gray matter at 7 T with an application to multiple sclerosis.Magn Reson Imaging 2010; 28:163-170.
  • 17.Filippi M,Agosta F.Magnetization transfer MRI in multiple sclerosis.J Neuroimaging 2007; 17 Suppl 1:22-26.
  • 18.Hayton T,Furby J,Smith KJ,Altmann DR,Brenner R,Chataway J,et al.Grey matter magnetization transfer ratio independently correlates with neurological deficit in secondary progressive multiple sclerosis.J Neurol 2009; 256:427-435.
  • 19.Tur C,Penny S,Khaleeli Z,Altmann D,Cipolotti L,Ron M,et al.Grey matter damage and overall cognitive impairment in primary progressive multiple sclerosis.Mult Scler 2011;17:1324-1332.
  • 20.Poonawalla AH,Hasan KM,Gupta RK,Ahn CW,Nelson F,Wolinsky JS,et al.Diffusion-tensor MR imaging of cortical lesions in multiple sclerosis:initial findings.Radiology 2008;246:880-886.
  • 21.Rovaris M,Agosta F,Pagani E,Filippi M.Diffusion tensor MR imaging.Neuroimaging Clin N Am 2009; 19:37-43.
  • 22.Inglese M,Park S J,Johnson G,Babb JS,Miles L,Jaggi H,et al.Deep gray matter perfusion in multiple sclerosis:dynamic susceptibility contrast perfusion magnetic resonance imaging at 3 T.Arch Neurol 2007; 64:196-202.
  • 23.Haacke EM,Garbem J,Miao Y,Habib C,Liu M.Imaging iron stores in the brain using magnetic resonance imaging.Magn Reson Imaging 2005; 23:1-25.
  • 24.Burgetova A,Seidl Z,Krasensky J,Horakova D,Vaneckova M.Multiple sclerosis and the accumulation of iron in the Basal Ganglia:quantitative assessment of brain iron using MRI T2 relaxometry.Eur Neurol 2010; 63:136-143.
  • 25.Ceccarelli A,Rocca MA,Neema M,Martinelli V,Arora A,Tauhid S,et al.Deep gray matter T2 hypointensity is present in patients with clinically isolated syndromes suggestive of multiple sclerosis.Mult Scler 2010; 16:39-44.
  • 26.Haacke EM,Makki M,Ge Y,Maheshwari M,Sehgal V,Hu J,et al.Characterizing iron deposition in multiple sclerosis lesions using susceptibility weighted imaging.J Magn Reson Imaging 2009; 29:537-544.
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