Changes in plasma hydrogen sulfide and nitric oxide levels and their clinical significance in children with Kawasaki disease
- Author:
- No author available
- Journal Title:
- Chinese Medical Journal
- Issue:
- 21
- DOI:
- 10.3760/cma.j.issn.0366-6999.2011.21.002
- Key Word:
- hydrogen sulfide;Kawasaki disease;nitric oxide
Abstract： Background Cardiac involvement is the most common complication of Kawasaki disease (KD); however,the underlying mechanisms are not understood.The present study was designed to investigate changes in plasma hydrogen sulfide (H2S) and nitric oxide (NO) levels in the acute and recovery stages of KD children and to examine their clinical significance.Methods Thirty-five KD patients and 32 healthy children were enrolled in the study.KD patients were divided into two subgroups:a non-cardiac involvement group and a cardiac involvement group.Plasma H2S levels were measured using the sulfur-sensitive electrode method and plasma NO levels and NO synthase activity were determined using the nitrate reductase method both before and after intravenous immune globulin (IVIG) therapy.Results Plasma H2S levels significantly decreased in KD patients during the acute phase of the disease and NO levels were significantly increased,compared with the control group (P ＜0.01).After treatment with IVIG,both plasma H2S and NO levels significantly increased (P ＜0.01).The plasma levels of H2S were significantly lower in the cardiac involvement group compared with the non-cardiac involvement group (P＜0.05).Conclusion H2S and NO may play a role in the pathophysiological process of inflammation during the acute phase of KD.Endogenous H2S may exert protective effects with respect to cardiac complications in KD.
- [1]Qiao W,Junbao D,Chaoshu T,etc.Endogenous hydrogen sulfide is involved in the pathogenesis of atherosclerosis.[J].2010,396(2).
- [2]Fiorucci S.Hydrogen sulfide: from physiology to pharmacology.[J].2011,10(2).
- [3]Rowley AH,Cornwall ML,Crawford SE,etc.Angiogenesis in fatal acute Kawasaki disease coronary artery and myocardium.[J].2005,26(5).
- [4]Bhatia M,Hegde A.Hydrogen sulfide in inflammation: friend or foe?[J].2011,10(2).
- [5]Wang XB,Jin HF,Tang CS,etc.Significance of endogenous sulphur-containing gases in the cardiovascular system.[J].2010,37(7).
- [6]Moreno L,Mitchell JA,Ali F,etc.Role of nitric oxide and prostacyclin as vasoactive hormones released by the endothelium.[J].2008,93(1).
- [7]Zagli G,Patacchini R,Gensini GF,etc.Hydrogen sulfide inhibits human platelet aggregation.[J].2007,559(1).
- [8]Bolger AF,Pallasch TJ,Taubert KA,etc.Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Associa[J].2004,114(6).
- [9]Tokarzewska D,Beltowski J,Jamroz Wisniewska A.Hydrogen sulfide and its modulation in arterial hypertension and atherosclerosis.[J].2010,8(4).
- [10]Bin G,Hui Y,Cheung Y,etc.The possible role of hydrogen sulfide as a smooth muscle cell proliferation inhibitor in rat cultured cells.[J].2004,19(2).
- [11]Ikemoto Y,Ogino H,Teraguchi M,etc.Evaluation of preclinical atherosclerosis by flow-mediated dilatation of the brachial artery and carotid artery analysis in patients with a history of Kawasaki disease.[J].2005,26(6).
- [12]K. Ikeda,K. Yamaguchi,T. Tanaka,etc.Unique activation status of peripheral blood mononuclear cells at acute phase of Kawasaki disease[J].2010,160(2).