Characteristics of the Chinese subjects entered the Hypertension in the Very Elderly Trial

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LIU Li-sheng(Beijing Hypertension League Institute, Beijing 100039, China)
Astrid Fletcher(Care of the Elderly, Hammersmith Hospital, Imperial College,London, UK)
Christopher J. Bulpitt(Care of the Elderly, Hammersmith Hospital, Imperial College,London, UK)
WANG Ji-guang(Centre for Epidemiological Studies and Clinical Trials, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine,Shanghai 200025, China)
MA Shu-ping(Department of Cardiology, Hebei Provincial Hospital,Shijiazhuang, Hebei 050051, China)
WANG Wen(National Centre for Cardiovascular Disease, Fuwai Hospital,Chinese Academy of Medical Sciences, Beijing 100037, China)
LU Fang-hong(Shandong Academy of Medical Sciences, Jinan, Shandong 050051,China)
ZHANG Liang-qing(Shanxi Cardiovascular Institute, Taiyuan, Shanxi 030001, China)
Winston Ban-ya(Care of the Elderly, Hammersmith Hospital, Imperial College,London, UK)
Ruth Peters(Care of the Elderly, Hammersmith Hospital, Imperial College,London, UK)
Nigel Beckett(Care of the Elderly, Hammersmith Hospital, Imperial College,London, UK)
Journal Title:
Volume 121, Issue 16, 2008
Key Word:

Abstract: Background The baseline characteristics of patients in a multinational trial are possibly related to cardiovascular outcome.This study compared the baseline Characteristics of patients recruited in China with those recruited in other countries.Methods A total of 508 Chinese hypertensive men and 728 women over the age of 80 years who entered the Hypertension in the Very Elderly Trial(HYVET)were compared with those in 860 men and 1 348 women who entered the trial in other countries.Results The Chinese subjects were slightly younger,had less previous hypertension but more previous strokes than the subjects from other countries.The Chinese subjects smoked more than those from other countries,but drank less alcoho1.They had less previous episodes of myocardial infarction and were,on average,lighter and shorter.The Chinese had lower mean concentrations of blood urea,uric acid and creatinine as well as higher concentrations of high density lipoprotein(HDL)cholesterol.The concentration of total cholesterol was,on average,lower in the Chinese subjects as was blood glucose.The levels of serum sodium and potassium,blood hematocrit and hemoglobin were all,on average,lower in the Chinese subjects.Conclusions Calorie restriction,compared with the rest of the world,may have resulted in lower stature and weight, and recent increases in calorie intake have not changed the metabolic profile of the very elderly hype~ensive patients in China.Some of these biochemical differences may reflect different dietary lifestyle in the Chinese.

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