Abstract： Background Jaw osteonecrosis possibly associated with the administration of bisphosphonates is expected to be treated with a non-pharmacologic approach.This study aimed to determine whether noninvasive,mechanically mediated vibration would inhibit the decline in bone mineral density(BMD)that follows menopause,enhance the BMD of the Iumbar and femoral neck.and reduce chronic back pain in postmenopausal women with osteoporosis.Methods A total of 116 postmenopausal women with osteoporosis participated in this study,and they were divided into groups A(66 patients)and B(50).Group A received vibration treatment(Subjects vertically stand on the vibration platform,with a vibration frequency of 30 Hz,amplitude of 5 mm:they received the treatment five times per week,ten minutes each time and totally for six months),whereas women of group B served as controls without any treatment.L2-4 BMD,bilateral femoral neck BMD,and body mass index(BMI)were recorded before the treatment or at the third and sixth months of the treatment respectively.After the ending of the treatment,the change of BMD in each group was compared and analyzed.Chronic back pain was evaluated by visual analogue scale(VAS)at baseline and the third and sixth months of the treatment.Results Of the 116 women,94 including 51 women from group A((61.23±8.20)years)and 43 women from group B ((63.73±5.45)years),completed the study.There were no significant differences in baseline characteristics including age,BMI,menopausal years,lumbar BMD,femoral neck BMD,and VAS between the two groups.The lumbar BMD of the 51 women in group A increased by 1.3%(P=0.034)after vibration treatment for 3 months and by 4.3% at the sixth month (P=0.000).The lumbar BMD in group B was decreased at theird month,but there was not statistical significance(P＞0.05).At the sixth month,it was decreased bv 1.9%(P＜0.05).The femoral neck BMD of the 51 women in group A was slightly Increased after vibration treatment for 3 months,but without statistical significance(P＞0.05).At the sixth month,the BMD was increased by 3.2%(P＜0.05).In group B,the BMD was not decreased significantly(P=0.185)at the third month,but decreased significantly at the sixth month(1.7%)(P＜0.05)compared with the baseline.Chronic back pain(VAS)reduced more significantly in group A at the third and the sixth months(P＜0.05)after vibration therapy in comparison with the baseline.The BMI was not significantly changed in the two groups dunng the penod of follow-up.Conclusions Vibration therapy appears to be useful in reducing chronic back pain and increasing the femoral neck and lumbar BMD in postmenopausal women with osteoporosis.