Aspergillus pneumonia in renal transplant recipients

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Author:
ZHANG Xiao-dong(Kidney Transplantation Program, Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020,China)
HU Xiao-peng(Kidney Transplantation Program, Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020,China)
YIN Hang(Kidney Transplantation Program, Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020,China)
WANG Wei(Kidney Transplantation Program, Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020,China)
ZHANG Xin(Kidney Transplantation Program, Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020,China)
MA Lin-lin(Kidney Transplantation Program, Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020,China)
WANG Yong(Kidney Transplantation Program, Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020,China)
Journal Title:
CHINESE MEDICAL JOURNAL
Issue:
Volume 121, Issue 09, 2008
DOI:
Key Word:
aspergillosis pneumonia; renal transplantation; diagnosis; treatment

Abstract: Background Filamentous fungal infections are associated with a high morbidity and mortality in solid organ transplants.The present study aimed to investigate the aspergillus pneumonia in renal transplant recipients, and its diagnosis as well as treatment.Methods Approximately 2000 cases of renal transplants were retrospectively studied and we focused on cases hospitalized during August 1, 2005 and February 1, 2007, as the study period. The clinical database and electronic records were analyzed. Recently published literature was reviewed.Results There was more diabetes and hypertension in the infected group than in the non-infected group (86% vs 62% and 57% vs 39%, respectively). Eighty-six percent of recipients from the infected group had delayed graft function. Seven cases with aspergillus pneumonia were identified based on either fungal culture or radiology. Of the 7 cases, 4 died in a few days after diagnosis. Liposomal amphotericin B was used as a first-line therapy.Conclusions Incidences of fungal infection are increasing among renal transplant recipients. Early diagnosis and treatment are critical steps in curing aspergillosis.

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