Plasma resistin is increased in patients with unstable angina
- Author:
- No author available
- Journal Title:
- CHINESE MEDICAL JOURNAL
- Issue:
- 10
- DOI:
- No doi available
- Key Word:
- resistin;unstable angina;inflammation;atherosclerosis
Abstract： Background Resistin, a novel adipokine linked to insulin resistance and obesity in rodents, which is derived mainly from macrophages and identified in atheromas in human, has been shown to play a potential role in atherosclerosis.Resistin levels were reported to increase in coronary artery disease (CAD), while data concerning resistin in different stages of CAD in Chinese people are lacking. The aim of this study was to assess whether plasma concentrations of resistin differed between patients with unstable and stable angina pectoris.Methods Plasma resistin levels were determined by means of enzyme-linked immunosorbent assay (ELISA) in 46 patients with unstable angina (UAP), 37 with stable angina (SAP) and 31 control subjects.Results Plasma concentrations of resistin were significantly increased in UAP group (geometric mean (interquartile range) 12.09 ng/ml (8.40, 18.08)) in comparison with SAP (9.04 ng/ml (7.09, 11.44)) and control groups (8.71 ng/ml (6.58,11.56)). No differences in resistin levels were found between patients with SAP and controls. We also found that plasma resistin positively correlated with leukocyte counts (r=0.21, P=0.027), high sensitive C-reactive protein (hs-CRP) (r=0.25,P=0.008), and endothelin-1 (r=0.21, P=0.025) after adjustment for age, sex and BMI.Conclusion Resistin may be involved in the development of CAD by influencing systemic inflammation and endothelial activation.
- [1]C, Rae,A, Graham.Human resistin promotes macrophage lipid accumulation.[J].2006,49(5).
- [2]Estrada E,Yiannakouris N,Mantzoros CS,etc.Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: cross-sectional and interventional studies in normal, insulin-resistant, and diabetic subjects.[J].2003,88(10).
- [3]Gentile L,Pagano GF,Bo S,etc.Relationships between human serum resistin, inflammatory markers and insulin resistance.[J].2005,29(11).
- [4]N, Al-Daghri,R, Chetty,P G, McTernan,etc.Serum resistin is associated with C-reactive protein & LDL cholesterol in type 2 diabetes and coronary artery disease in a Saudi population.[J].2005,4(1).
- [5]Bluher S,Mantzoros CS,Yannakoulia M,etc.Body fat mass and macronutrient intake in relation to circulating soluble leptin receptor, free leptin index, adiponectin, and resistin concentrations in healthy humans.[J].2003,88(4).
- [6]Dahlberg L,Smith U,Nagaev I,etc.Resistin, an adipokine with potent proinflammatory properties.[J].2005,174(9).
- [7]G M, Rubanyi,M A, Polokoff.Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology.[J].1994,46.
- [8]Tataranni PA.High Serum Resistin Is Associated With an Increase in Adiposity But Not a Worsening of Insulin Resistance in Pima Indians.[J].2004,53(5).
- [9]Shen YH,Zhang L,Gan Y,etc.Up-regulation of PTEN (phosphatase and tensin homolog deleted on chromosome ten) mediates p38 MAPK stress signal-induced inhibition of insulin signaling. A cross-talk between stress signaling and insulin signaling in resistin-treated human endothelia[J].2006,281(12).
- [10]Burnett MS,Lindsay R,Devaney JM,etc.Cross-sectional associations of resistin, coronary heart disease, and insulin resistance.[J].2006,91(1).
- [11]Michael, Lehrke,Muredach P, Reilly,Segan C, Millington,etc.An inflammatory cascade leading to hyperresistinemia in humans.[J].2004,1(2).
- [12]Ahima RS,Scherer PE,Pajvani UB,etc.Regulation of resistin expression and circulating levels in obesity, diabetes, and fasting.[J].2004,53(7).
- [13]Barnett AH,Fisher FM,Valsamakis G,etc.Resistin and type 2 diabetes: regulation of resistin expression by insulin and rosiglitazone and the effects of recombinant resistin on lipid and glucose metabolism in human differentiated adipocytes.[J].2003,88(12).
- [14]Veves A,Shetty GK,Economides PA,etc.Circulating adiponectin and resistin levels in relation to metabolic factors, inflammatory markers, and vascular reactivity in diabetic patients and subjects at risk for diabetes.[J].2004,27(10).
- [15]Subodh Verma,Shu-Hong Li,Chao-Hung Wang,etc.Resistin Promotes Endothelial Cell ActivationFurther Evidence of Adipokine-Endothelial Interaction[J].2003,108(6).
- [16]Sul HS,Lee K,Kim KH,etc.A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation.[J].2001,276(14).
- [17]Steppan CM,Wright CM,Dai CY,etc.A family of tissue-specific resistin-like molecules.[J].2001,98(2).
- [18]C M, Steppan,S T, Bailey,S, Bhat,etc.The hormone resistin links obesity to diabetes.[J].2001,409(6818).