Clinical and pathological characteristics of septum pellucidum tumor and choice of surgical approaches for its resection

( views:108, downloads:0 )
Author:
WANG Lei()
ZHANG Mao-zhi()
ZHANG Wei()
ZHAO Shang-feng()
Zhao Ji-zong()
JIA Jin-xiu()
Journal Title:
CHINESE MEDICAL JOURNAL
Issue:
Volume 118, Issue 10, 2005
DOI:
Key Word:
septum pellucidum;intracranial tumor;central neurocytoma;surgery;minimal invasion

Abstract´╝Ü Background Tumor involving the septum pellucidum is uncommon. Surgery as the main therapeutic procedure for this lesion is a challenge to neurosurgeons. We analyzed the clinical characteristics and pathological features of septum pellucidum tumor in 41 patients and compared the curative effects of frontal transcortical, trans-sulcal and interhemispheric transcallosal approaches. Methods Clinical characteristics and the pathological features of septum pellucidum tumor were investigated retrospectively in 41 patients. The differences in postoperative residual rates, extents of tumors and resection of normal brain tissues after use of the three approaches in these patients were analyzed statistically. Results Septum pellucidum tumor is more likely to attack young or middle-aged persons. The tumor mainly presents itself as a central neurocytoma or cerebral low-grade glioma in pathology and manifests as intracranial hypertension clinically. No difference was found in the extent of tumor resection but significant difference in the extent of normal brain tissue resection and in postoperative disability rate among the three approaches. The transcortical approach brought about the most serious injury to brain tissue and the highest disability rate, Whereas the frontal transcallosal approach the lightest injury and the lowest disability rate. The injury to brain tissue and the disability rate brought about by the front trans-sulcus approach were between the above two approaches. Conclusions Operation is still regarded the major treatment for septum pellucidum tumor. Transcallosal and trans-sulcus approaches are fit with the concept of minimally invasive surgery, and transcallosal approach is the first choice for septum pellucidum tumor.

  • [1]Schmidt MH; Gottfried ON, Koch CS, et al. Central neurocytoma: a review. J Neueooncol 2004;66:377-384.
  • [2]Timurkaynak E, Rhoton AL Jr, Barry M. Microsurgical anatomy and operative approach to the lateral ventrical. Neurosurgery 1986;19:685-723.
  • [3]Hassonu J, Soylemezoglu F, Gambarell D, et al. Central neurocytoma: a synopsis of clinical and histological features. Brain Pathol 1993;3:297-306.
  • [4]Rades D, Fehlauer F. Treatment options for central neurocytoma. Neurology 2002;59:1268-1270.
  • [5]Asgari S, Engelhorn T, Brondics A, et al. Transcortical or transcallosal approach to ventrical-associated lesions: a clinical study on the prognostic role of surgical approach. Neurosurg Rev 2003;26:192-197.
  • [6]Apuzzo ML, Chikovani OK, Goor PS, et al. Transcallosal interfornical approaches for lesions affecting the third ventricle: surgical considerations and consequences. Neurosurgery 1982;10:547-554.
  • [7]Zhang MZ, Wang L, Zhao JiZ, et al.The transcortical approach for lesions affecting the trigone area of the lateral ventricles. China Minimal Invasive Neurosurg (Chin) 2003;8:59-61.
  • [8]Yasargil MG, Ammon KV, von Deimling A, et al. Central neurocytoma: histopathological variants and therapeutic approaches. J Neurosurg 1992;76:32-37.
  • [9]Belloti C, Pappada G, Sani R, et al. The transcallosal approach for lesions affecting the lateral and third ventricles: surgical considerations and results in a series of 42 cases. Acta Neurochir (Wein) 1991;111:103-107.
  • [10]Pepmieier JM, Spencer DD, Sass KJ, et al. Lateral ventrical masses. In Apuzzo ML, ed, Brain neurosurgery: complication avoidances and mange-ment. New York: Churchill Livingstone; 1993:581-600.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn