Effects of hormone replacement therapy on platelet activation in postmenopausal women
- Author:
- No author available
- Journal Title:
- CHINESE MEDICAL JOURNAL
- Issue:
- 8
- DOI:
- No doi available
- Key Word:
- hormone replacement therapy;menopause;platelet activation
Abstract： Objective To assess the effects of hormone replacement therapy (HRT) on platelet activation in postmenopausal women compared with premenopausal women. Methods The expressions of CD41 and CD62P in fifteen postmenopausal women before and after HRT were detected using flow cytometry (FCM), with fifteen premenopausal women with a mean age of 47 years as controls.Results The expressions of CD41 and CD62P in postmenopausal women were higher than those in the control group. CD62P(%), CD62P(I) and CD41 were reduced from 36.40±5.9, 37.75±5.8, and 470.11±74.0 to 27.97±5.6, 26.64±4.9, and 303.23±72.8 after six months of HRT (P<0.05). Conclusions Platelet activation in postmenopausal women was higher than in premenopausal women and was reduced significantly after six months of HRT. HRT may have a favorable effect on reduction of platelet activity.
- [1]I I, Surya,J W, Akkerman.The influence of lipoproteins on blood platelets.[J].1993,125(1).
- [2]Francine Grodstein,Meir J Stampfer,Samuel Z Goldhaber,etc.Prospective study of exogenous hormones and risk of pulmonary embolism in women[J].1996,348(9033).
- [3]Shweiki D,Itin A,Neufeld G,etc.Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis.[J].1993.
- [4]Edel Daly,Martin P Vessey,Michael M Hawkins,etc.Risk of venous thromboembolism in users of hormone replacement therapy[J].1996,348(9033).
- [5]Craig H Selzman MD,Thomas A Whitehill MD,Brian D Shames MD,etc.The Biology of Estrogen-Mediated Repair of Cardiovascular Injury[J].1998,65(3).
- [6]Fuster V,Badimon JJ,Vorchheimer DA.Platelet glycoprotein IIb/IIIa receptor antagonists in cardiovascular disease.[J].1999,281(15).
- [7]I, Spyridopoulos,A B, Sullivan,M, Kearney,etc.Estrogen-receptor-mediated inhibition of human endothelial cell apoptosis. Estradiol as a survival factor.[J].1997,95.
- [8]M J, Tikkanen,E A, Nikkila,E, Vartiainen.Natural oestrogen as an effective treatment for type-II hyperlipoproteinaemia in postmenopausal women.[J].1978,2(8088).