Abstract： Objective To investigate therapeutics for and the pathological basis of combined radiation and bur*$ n injuries.Methods Combined radiation and bur*$ n injuries on mice and rats were inflicted by γ ray irradiation from a 60 Co source and thermal radiation from a 5 kW bromotungsten lamp.Results The dysfunction of myocardium played an important role in the development of early stage shock. Transfusion of irradiated (in vitro, 20 Gy) or stored (4℃, 7 days) blood after irradiation was done to promote the success of allo-transplantation of bone marrow. Decrease of IL-4 mRNA expression was the molecular basis of depression of intestinal mucosa immune and intervention of IL-4 showed an antagonistic effect on enterogenic infection. A new lipid component extracted from bur*$ n eschar was documented for the first time and its toxic effects were elucidated. The survival rate of alloskin grafts after removal of bur*$ n eschar from the recipient animals was obviously increased in combined injury due to reduction of immune rejection activity by the radiation effect. In contrast, in animal models with simple bur*$ n, the alloskin grafts were all rejected within ten days after the procedure. A successful therapeutic result (survival rate: 92% for 30 days and 67% for 100 days) was obtained by comprehensive management of treated animals, while the untreated control animals all died within 3-7 days after injury.Conclusion The pathogenesis of injury caused by simultaneous radiation and bur*$ n is extremely complicated and the treatment is very difficult. A comprehensive management program consisting of several therapeutic measures aimed at key links of the pathogenesis may achieve significantly improved results.