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A selective reduction in the relative density of parvalbumin-immunoreactive neurons in the hippocampus in schizophrenia patients

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Author:
No author available
Journal Title:
CHINESE MEDICAL JOURNAL
Issue:
6
DOI:
10.3760/cma.j.issn.0366-6999.2002.06.104
Key Word:
γ-氨基丁酸能中间神经元 parvalbumin calretinin 海马 人脑 精神分裂症;GABAergic interneurons;parvalbumin;calretinin;hippocampus;human brain;schizophrenia

Abstract: Objectives To determine the relative densities of the GABAergic subpopulation defined by calcium-binding proteins and to further study the importance of changes in GABAergic interneurons on neuropathology in the hippocampus in schizophrenia cases. Methods The relative densities and neuronal body size of cells immunoreactive for the calcium-binding proteins parvalbumin and calretinin as well as the area size of the hippocampal sub-fields were determined from the hippocampal tissue sections taken from schizophrenic patients and well-matched control subjects (15 per group). Results No significant difference in the density of calretinin-immunoreactive neurons and the neuronal body size of calretinin-positive neurons was found between subject groups. Relative to normal controls, schizophrenic patients showed a significant and profound deficit in the relative densities of parvalbumin-immunoreactive neurons in all hippocampal sub-fields. These reductions were more apparent in male schizophrenic patients and were unrelated to antipsychotic drug treatment, age or duration of illness. Conclusion The findings provide further evidence to support a profound and selective abnormality of a sub-population of GABAergic neurons in the hippocampus in schizophrenia cases, and are consistent with the etiological hypothesis of the neurodevelopment of schizophrenia.

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