Abstract： Objective To clone the full length of renal cell carcinoma (RCC) related novel gene GYLZ -RCC18 and study its function.Methods SMART RACE technology was used to clone the full length of GYLZ-RCC18. RT-PCR was used to detect its expression in renal cell carcinoma tissue at different s tages and grades. We transfected the antisense oligonucleotide of GYLZ-RCC18 t o renal cell carcinoma cell line, GRC-1, and analyzed proliferation activity, g rowth rate, apoptosis, and mortality changes.Results The full length of GYLZ-RCC18 (GenBank accession number: BE825133) cDNA was abo ut 3.5kb. GYLZ-RCC18 had a higher expression in higher grades and stage s of renal cell carcinoma than in lower ones. The expression of GYLZ-RCC18 in rena l cell carcinoma was much higher than in normal kidney. After the transfection of GYLZ-RCC18 antisense oligonucleotide, the mortality of GRC-1 increased sig nificantly, while proliferative activity and growth rate were substantially inhi bited at the same time. The antisense oligonucleotide induced apoptosis of GRC -1 through the entire observation time.Conclusion GYLZ-RCC18 is an important novel gene related to renal cell carcinoma. Overexp ression of this gene results in higher growth and proliferative activity and has an antiapoptosis effect on renal cell carcinoma cells. Transfection of the ant isense oligonucleotide may inhibit the generation and development of renal cell carcinoma.