Linkage analysis of a region on chromosome 2 with essential hypertension in Ch inese families
- Author:
- No author available
- Journal Title:
- CHINESE MEDICAL JOURNAL
- Issue:
- 5
- DOI:
- 10.3760/j.issn:0366-6999.2002.05.003
- Key Word:
- 高血压;基因;连锁分析;hypertension;gene;linkage analysis
Abstract： Objective To verify the linkage of the candidate regions identified in a previous study (m arkers D2S168, D2S151, D2S142 on chromosome 2) with hypertension in Chinese fami lies.Methods A genetic linkage study focused on chromosome 2 was performed on 240 Chinese fam ilies containing 856 patients with essential hypertension. A total of 1080 indi viduals were genotyped using 9 highly polymorphic microsatellite markers around the candidate regions on chromosome 2 with an average spacing of 5cM. Non-pa rametric linkage (NPL), parametric linkage analysis and transmission-disequilib rium test (TDT) with the GENEHUNTER software were used to assess evidence for li nkage.Results Linkage of a region on chromosome 2 around D2S151 and D2S142 with hypertension w as confirmed by different statistical methods (NPL, LOD score and TDT). However , the linkage of D2S168 could not be replicated in this extension study.Conclusions The data suggest that a region on chromosome 2 at or near the loci of D2S142 and D2S151 may harbor genes responsible for the development of essential hypertensi on in Chinese.
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