Abstract： Objective To assess the effect of transcatheter closure of patent ductus arteriosus (PDA) by comparing five different devices.Methods 354 patients (135 males, 219 females) underwent transcatheter closure of PDA using the Porstmann Ivalon plug, Rashkind double umbrella, Sideris button device, Coils and Amplatzer occluders.The mean PDA diameter at its narrowest segment was 3.1 ± 1.3 mm. Qp/Qs was 2.2 ± 0.5. Follow-up evaluation was performed with color flow mapping of the main pulmonary artery at 24 h and 6 months after closure.Results Successful occlusion was observed in 92％ (23/25) for the Porstmann device, 98.7％ (77/78)for the Rashkind device, 100％ (43/43) for the Sideris device, 100％ (69/69) for the Coil and 100％(139/139) for the Amplatzer device. No residual shunts were needed for the Porstmann, while 1.4％ -15％ of patients who received the Rashkind, Sideris, coils or Amplatzer needed residual shunts during follow-up. There were complications of 24％ (6/25) for the Porstmann, 3.8％ (3/78) for the Rashkind,1.4％ (1/69) for Coils and 1.4％ (2/139) for the Amplatzer. No complications were found in patients with the Sideris device.Conclusion The results showed that the Sideris device, coils and the Amplatzer device are more effective and safer than the others for the occlusion of PDA in children.