Studies on the effect and mechanism of aerobic exercise on patients with metabolic syndrome

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SHEN Xuan-lin(Department of Rehabilitation, The Affiliated Changshu Hospital of Yangzhou University Medical College, Changshu 215500, China)
LIU Sui-xin()
Journal Title:
Journal of Chinese Physician
Volume 14, Issue 09, 2012
Key Word:
Metabolic syndrome X/therapy;Exercise therapy

Abstract: Objective To explore the effect of aerobic exercise on serum leptin,interleukin-18 (IL-18),soluble intercellular adhesion molecule-1 (sICAM-1),C reaction protein (CRP) concentration,and homeostasis model assessment insulin resistance (HOMA-IR) of patients with metabolic syndrome ( MS),and to explore its mechanism.Methods Forty sedentary patients with MS were randomly divided into exercise group and fenofibrate group.Patients in exercise group were trained at anaerobic threshold intensity (30 min/times) for 12 weeks (5 times/wk).Patients in fenofibrate group were treated with fenofibrate 200 mg every night.Serum leptin,IL-18,CRP,and sICAM-1 concentration were measured by enzyme linked immunosorbent assay (ELISA).Twenty healthy subjects were selected as the control group.Results Serum concentration of leptin [ ( 26.04 ± 9.07 ) ng/ml vs ( 8.32 ± 2.94 ) ng/ml,t =12.72,P <0.01 ],IL-18[ (308.27 ±50.39)pg/ml vs (230.60 ±29.15)pg/ml,t =6.41,P <0.01 ],CRP[ (2.65±0.57)ng/ml vs ( 1.26 ±0.23) ng/ml,t =9.69,P <0.01 ],sICAM-1 [ (331.89 ±60.08) ng/ml vs (246.43±39.32)ng/ml,t =5.98,P <0.01],and HOMA-IR(4.38 ±2.06 vs 2.12 ± 0.50,t =4.81,P < 0.01 ) of patients with MS were significantly increased compared to the control.Serum concentration of leptin[(26.38±10.85)ng/ml vs (19.63 ±6.27)ng/ml,t =2.22,P <0.05],IL-18[(309.40 ±49.77)pg/ml vs (291.80 ±39.21)pg/ml,t =2.33,P <0.05],CRP[ (2.73 ±0.72)ng/ml vs (2.28 ±0.38)ng/ml,t =3.41,P <0.01 ],sICAM-1 [ (333.85 ±55.97) ng/ml vs (306.24 ±50.55) ng/ml,t =3.16,P <0.01],and HOMA-IR(4.53 ±2.39 vs 2.89 ±0.69,t =2.87,P <0.01 ) were significantly decreased after training for 12 weeks.Conclusions Aerobic exercise is one of the effective treatments of patients with MS.Its underlying mechanism may be associated with reduction of serum inflammatory adipokine concentration,and improvement of vascular endothelial function and insulin resistance.

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