Studies on the effect and mechanism of aerobic exercise on patients with metabolic syndrome

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Author:
SHEN Xuan-lin(Department of Rehabilitation, The Affiliated Changshu Hospital of Yangzhou University Medical College, Changshu 215500, China)
LIU Sui-xin()
Journal Title:
Journal of Chinese Physician
Issue:
Volume 14, Issue 09, 2012
DOI:
10.3760/cma.j.issn.1008-1372.2012.09.007
Key Word:
Metabolic syndrome X/therapy;Exercise therapy

Abstract: Objective To explore the effect of aerobic exercise on serum leptin,interleukin-18 (IL-18),soluble intercellular adhesion molecule-1 (sICAM-1),C reaction protein (CRP) concentration,and homeostasis model assessment insulin resistance (HOMA-IR) of patients with metabolic syndrome ( MS),and to explore its mechanism.Methods Forty sedentary patients with MS were randomly divided into exercise group and fenofibrate group.Patients in exercise group were trained at anaerobic threshold intensity (30 min/times) for 12 weeks (5 times/wk).Patients in fenofibrate group were treated with fenofibrate 200 mg every night.Serum leptin,IL-18,CRP,and sICAM-1 concentration were measured by enzyme linked immunosorbent assay (ELISA).Twenty healthy subjects were selected as the control group.Results Serum concentration of leptin [ ( 26.04 ± 9.07 ) ng/ml vs ( 8.32 ± 2.94 ) ng/ml,t =12.72,P <0.01 ],IL-18[ (308.27 ±50.39)pg/ml vs (230.60 ±29.15)pg/ml,t =6.41,P <0.01 ],CRP[ (2.65±0.57)ng/ml vs ( 1.26 ±0.23) ng/ml,t =9.69,P <0.01 ],sICAM-1 [ (331.89 ±60.08) ng/ml vs (246.43±39.32)ng/ml,t =5.98,P <0.01],and HOMA-IR(4.38 ±2.06 vs 2.12 ± 0.50,t =4.81,P < 0.01 ) of patients with MS were significantly increased compared to the control.Serum concentration of leptin[(26.38±10.85)ng/ml vs (19.63 ±6.27)ng/ml,t =2.22,P <0.05],IL-18[(309.40 ±49.77)pg/ml vs (291.80 ±39.21)pg/ml,t =2.33,P <0.05],CRP[ (2.73 ±0.72)ng/ml vs (2.28 ±0.38)ng/ml,t =3.41,P <0.01 ],sICAM-1 [ (333.85 ±55.97) ng/ml vs (306.24 ±50.55) ng/ml,t =3.16,P <0.01],and HOMA-IR(4.53 ±2.39 vs 2.89 ±0.69,t =2.87,P <0.01 ) were significantly decreased after training for 12 weeks.Conclusions Aerobic exercise is one of the effective treatments of patients with MS.Its underlying mechanism may be associated with reduction of serum inflammatory adipokine concentration,and improvement of vascular endothelial function and insulin resistance.

  • [1]Cox KL,Burke V,Morton AR,et al.Independent and additive effects of energy restriction and exercise on glucose and insulin concentrations in sedentary overweight men. Am J Clin Nutr,2004,80(2):308-816.
  • [2]中华医学会糖尿病学分会代谢综合征研究协作组.中华医学会糖尿病学分会关于代谢综合征的建议.中华糖尿病杂志,2004,12(3):156-161.
  • [3]Seshadri P,Samaha FF,Stern L,et al.Free fatty acids,insulin resistance,and corrected qt intervals in morbid obesity:effect of weight loss during 6 months with differing dietary interventions.Endocr Pract,2005,11 (4):234-239.
  • [4]沈玄霖,刘遂心.代谢综合征的综合治疗.心血管康复医学杂志,2007,16(4):415-417.
  • [5]高璐,于德民.罗格列酮对非糖尿病代谢综合征患者糖脂代谢、胰岛素抵抗及炎症指标的影响.中国糖尿病杂志.2009,17(2):109-110
  • [6]叶建红,舒晓春,陈苹,等.代谢综合征患者葡萄糖代谢率与血浆脂联素及瘦素水平变化的关系.中华医学杂志,2011,91(16):1088-1091.
  • [7]Krogh-Madsen R,Plomgaard P,Moller K,et al.Influence of TNF-alpha and IL-6 infusions on insulin sensitivity and expression of IL-18 in humans.Am J Physiol Endocrinol Metab,2006,291:E108-E114.
  • [8]刘文卫,刘永胜,江华,等.冠心病合并2型糖尿病患者血清白介素-18水平检测.中国医师杂志,2007,9(6):834-835.
  • [9]周秀华,李冬梅.心脏泵衰竭患者血清可溶性细胞间黏附因子-l与抵抗素水平的研究.中国医师杂志,2010,12(1):116-117.
  • [10]Hsu LA,Ko YL,Wu S,et al.Association of soluble intercellular adhesion molecule-1 with insulin resistance and metabolic syndrome in Taiwanese.Metabolism,2009,58 (7):983-988.
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