Study on the optimal dosage of Dezocine combined with propofol used in painless induced abortion

( views:320, downloads:0 )
Author:
HUANG Shou-yin(Department of Anesthesiology, Puyang People's Hospital, Puyang 457000, China)
YUE Xiu-qin()
Journal Title:
Journal of Chinese Physician
Issue:
Volume 14, Issue 09, 2012
DOI:
10.3760/cma.j.issn.1008-1372.2012.09.006
Key Word:
Propofol/administration & dosage;Cycloparaffins/administration & dosage;Abortion, induced;Analgesia, obstetrical/methods

Abstract: Objective To investigate the clinical effect,suitable dose,and its safety of dezocine combined with propofol used in painless artificial abortion.Methods With a completely randomized double blind method,200 cases of ASA Ⅰ or Ⅱ early intrauterine pregnancy patients were divided into A,B,C,and D four groups ( n =50).Each patient in A,B,and C groups was infused dezocine in 0.10,0.15,and 0.20 mg/Kg,respectively.D group was administrated with intravenous fentanyl 1.5 μ g/kg,then 3min later,slowly intravenous injection of 1% of propofol.MAP,HR,RR,and SpO2 were recorded at the before anesthesia induction (T0 ),loss of eyelash reflex time (T1 ),recovery time (T2),and recovery 10 -min time (T3 ).Meanwhile,the parameters including the anesthesia induction time,anesthesia recovery time,directional force recovery time,induction dosage and total dosage of propofol,and the intraoperative and postoperative analgesic efficacy and adverse reaction were compared among different groups.Results For the A and D groups,MAP,HR,RR,and SpO2 at the T1 were all lower than that at the T0 ( P <0.05).For the B group,MAP and HR at the T1 were lower than that at the T0 ( P < 0.05).The anesthesia recovery time and orientation recovery time in the B and C groups were significantly shorter than A and D groups ( P < 0.05 ),and significantly statistical difference was found between A and D groups,no statistical difference between B and C groups ( P > 0.05).The propofol induction dosage and total dosage were different among groups ( groups C < B < D < A) with a statistical significance ( P < 0.05 ).The intraoperarive analgesia effect,postoperative pain score grading,and intraoperative body dynamic reaction rates in the B and C groups were significantly different from the A and D groups ( P < 0.05 ),and no statistical significance was found between B and C groups ( P > 0.05 ).The respiratory inhibition,postoperative nausea,vomiting and other adverse reaction rates in the B and C groups were significantly lower than those in A and D groups ( P < 0.05),and those parameters in B group were lower than C group.Conclusions Dezocine combined with propofol is definitely effective and very safe in painless induced abortion with very less respiratory inhibition,nausea,vomiting,and other adverse reactions; and their optimal dosage is 0.15 mg/kg.

  • [1]乐杰.妇产科学.7版.北京:人民卫生出版社,2008:312-313.
  • [2]罗焕光,赵莉,邱为民.枸橼酸芬太尼复合丙泊酚用于现症精神分裂症孕妇无痛人流术.广东医学,2010,31 (14):1832-1834.
  • [3]Vlahos NF,Giannakikou I,Vlachos A,et al.Analgesia and anesthesia for assisted reproductive technologies.Int J Gynaecol Obstet,2009,105 (3):201-205.
  • [4]Bajwa S J,Bajwa SK,Kaur J.Comparison of epidural ropivacaine and ropivacaine clonidine combination for elective cesarean sections.Saudi J Anaesth,2010,4(2):47-54.
  • [5]董国良,陶怡怡,苏静.异丙酚靶控输注及复合不同镇痛药在门诊无痛人工流产手术麻醉中的临床对比.上海医学,2004,27(2):122-125.
  • [6]王玲,任洪智,叶铁虎,等.异丙酚用于人工流产手术麻醉的临床观察.中华麻醉学杂志,1993,14(2):90.
  • [7]胡志平,佘守章.异丙酚用于门诊人流的临床疗效观察.广东医药,1999,9(3):36.
  • [8]张立君,王安的,袁晓荒,等.丙泊酚致无痛人流患者短暂精神功能障碍4例.四川医学,2006,27(12):1314-1315.
  • [9]高新明,陈瑞生,伍彩雯,等.异丙酚用于人工流产所致并发症及处理.临床麻醉学杂志,2001,17(1):37.
  • [10]Coats SJ,Schulz MJ,Carson JR,et al.Parallel methods for the preparation and SAR exploration of N-ethyl-4-[(8-alkyl-8-aza-bicyclo[3.2.1]oct-3-ylidene)-aryl-methyl]-benzamides,powerful mu and delta opioid agonists.Bioorg Med Chem Lett.2004,14(22):5493-5498.
  • [11]Cohen RI,Edwards WT,Kezer EA,et al.Serial intravenous doses of dezocine,morphine,and nalbuphine in the management of postoperative pain for outpatients.Anesth Analg,1993,77 (3):533-539.
  • [12]Dockendorff C,Jin S,Olsen M,et al.Discovery of mu-opioid selective ligands derived from 1-aminotetralin scaffolds made via metal-catalyzed ring-opening reactions.Bioorg Med Chem Lett,2009,19 (4):1228-1232.
  • [13]Gharagozlou P,Hashemi E,DeLorey TM,et al.Pharmacological profiles of opioid ligands at kappa opioid receptors.BMC Pharmaco1,2006,6:3.
  • [14]Los GJ,Lauwers MH,Van Lersberghe C,et al.Influence of sufentanil on propofol anesthesia using a target controlled infusion system.Acta Anaesthesiol Belg,1995,46 (3-4):153-159.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn