Study on the dynamic characteristics and pathological mechanism of magnatic resonance diffusion weighted imaging after chemoembolizaiton in rabbit liver VX-2 tumor model

( views:293, downloads:0 )
YUAN You-hong(Department of Radiology, Hunan Provincial People's Hospital,Changsha 410005, China)
CHEN Wei-jian()
PENG Zi-wen()
XIAO En-hua()
WANG Ke-yi(Department of Radiology, Hunan Provincial People's Hospital,Changsha 410005, China)
LIU Jian-bin(Department of Radiology, Hunan Provincial People's Hospital,Changsha 410005, China)
HE Zhong()
JIN Ke()
MA Cong()
XIAO Jie-hua()
Journal Title:
Journal of Chinese Physician
Volume 14, Issue 09, 2012
Key Word:
Magnetic resonance imaging;Liver neoplasms,experimental/drug therapy;Liver neoplasms,experimental/pathology;Chemoembolization,therapeutic;Rabbits

Abstract: Objective To investigate its dynamic characteristics and pathological mechanism on magnatic resonance diffusion weighted imaging (DWI) after chemoembolization in rabbit liver VX-2 tumor model.Methods Forty New Zealand rabbits were included in the study and forty-seven rabbit VX-2 tumor models were raised by implanting directly and intrahepatically after abdominal cavity was opened.Forty VX-2 tumor models from them were divided into four groups.DWI was performed periodically and respectively for each group after chemoembolization.All VX-2 tumor samples of each group were studied by pathology.The distinction of VX-2 tumors on DWI was assessed by their apparent diffusion coefficient (ADC) values.The statistical significance between different time groups,different area groups,or different b-value groups was calculated using SPSS 12.0 software.Results When b-value was 100 s/mm2,ADC values in the area of VX-2 tumor periphery,VX-2 tumor central,or normal liver parenchyma around tumor became gradually low in sixteen hours after chemoembolization,and were the lowest at sixteenth hour,and then they increased gradually from sixteenth hour to fourty-eighth hour after chemoembolization.The distinction of ADC between different time groups was significant,respectively ( F =7.325,P < 0.01 ; F =2.496,P < 0.05 ; F =6.856,P <0.01 ).Cellular edema in the area of VX-2 tumor periphery or normal liver parenchyma around tumor increased quickly in sixteen hours after chemoembolization; however,from sixteenth hour to forty-eighth hour,cellular edema in the area of normal liver parenchyma around tumor decreased gradually and that in the area of VX-2 tumor periphery decreased lightly at first and then increased continually.Cellular necrosis in the area of VX-2 tumor periphery after chemoembolization was more significant than that before chemoembolization.The areas of dead cells in VX-2 tumors manifested low signal and high ADC value while the areas of viable cells manifested high signal and low ADC value.Conclusions DWI is able to detect and discriminate tumor necrotic areas from viable cellular areas before and after chemoembolization.ADC of normal liver parenchyma and VX-2 tumor are influenced by intracellular edema,tissue cellular death,and microcirculation disturbance after chemoembolization.

  • [1]Somford DM,Marks MP,Thijs VN,et al.Association of early CT abnormalities,infarct size,and apparent diffusion coefficient reduction in acute ischemic stroke.Am J Neuroradiol,2004,25 (6):933-938.
  • [2]Brugieres P,Thomas P,Maraval A,et al.Water diffusion compartmentation at high b values in ischemic human brain.Am J Neuroradiol,2004,25 (5):692-698.
  • [3]Mitsias PD,Ewing JR,Lu M,et al.Multiparametric iterative selforganizing MR imaging data analysis technique for assessment of tissue viability in acute cerebral ischemia. Am J Neuroradiol,2004,25 (9):1499-1508.
  • [4]Taouli B,Martin AJ,Qayyum A,et al.Parallel imaging and diffusion tensor imaging for diffusion-weighted MRI of the liver:preliminary experience in healthy volunteers. Am J Roentgenol,2004,183 (3):677-680.
  • [5]孙希杰,全显跃,粱文,等.3cm以下的肝脏常见病变磁共振扩散成像的量化研究.中华肿瘤杂志,2004,26(3):165-167.
  • [6]Moteki T,Horikoshi H,Oya N,et al.Evaluation of hepatic lesions and hepatic parenchyma using diffusion-weighted reordered turboFLASH magnetic resonance images.J Magn Reson Imaging,2002,15 (5):564-572.
  • [7]杨正汉,谢敬霞,章跃武,等.肝硬化的磁共振扩散加权成像研究.中国医学影像技术,2002,18(9):907-909.
  • [8]Kamel IR,Bluemke DA,Ramsey D,et al.Role of diffusionweighted imaging in estimating tumor necrosis after chemoembolization of hepatocellular carcinoma.Am J Roentgenol,2003,181(3):708-710.
  • [9]Geschwind JF,Artemov D,Abraham S,et al.Chemoembolization of liver tumor in a rabbit model:assessment of tumor cell death with diffusion-weighted MR imaging and histologic analysis.J Vasc Interv Radiol,2000,11 (10):1245-1255.
  • [10]Colagrande S,Politi LS,Messerini L,et al.Solitary necrotic nodule of the liver:imaging and correlation with pathologic features.Abdom Imaging,2003,28(1):41-44.
  • [11]王建利,谢敬霞.MR灌注及扩散成像在脑血液动力学与急性脑缺血病理生理研究中的应用.中华放射学杂志,1998,32(6):370-374.
  • [12]肖学宏,孔祥泉,江利,等.急性脑缺血及再灌注磁共振扩散加权成像的特点.中华放射学杂志,1999,33(10):662-666.
  • [13]谢敬霞,付瑜,张燕,等.脑缺血区水分子扩散变化及其临床应用.北京大学学报:医学版,2001,33(2):109-112.
  • [14]韩鸿宾,谢敬霞.MR扩散与灌注成像在脑缺血诊断中的应用.中华放射学杂志,1998,32(6):364-369.
  • [15]Marks MP,De Crespignya,Lentz D,et al.Acute and chronics troke:navigated spin-echo diffusion-weighted MRimaging.Radiology,1996,199(3):403-408.
  • [16]聂国青,杨明英,庄明霞,等.化疗药物型栓塞剂在肝癌介入治疗中的疗效观察.现代肿瘤医学,2010,18(7):1382-1383.
  • [17]Huppert P.Current concepts in transarterial chemoembolization of hepatocellular carcinoma.Abdom Imaging,2011,36 (6):677-683.
  • [18]李泽信,王霄,朱绍辉,等.肝癌介入治疗对多药耐药相关蛋白基因表达的影响.中国现代普通外科进展,2010,13(12)925-928.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615