The effect of PARP in heart ischemia/reperfusion injury in rats
- Author:
- No author available
- Journal Title:
- Journal of Chinese Physician
- Issue:
- 8
- DOI:
- 10.3760/cma.j.issn.1008-1372.2012.08.007
- Key Word:
- 聚ADP核糖聚合酶类;心肌再灌注损伤;细胞凋亡;Poly(ADP-ribose)polymerases;Myocardial reperfusion injury;Apoptosis
Abstract： Objective To investigate the effect of Poly (ADP-ribose) polymerase(PARP) in heart ischemia/reperfusion (I/R) injury in rats.Methods Forty - eight rats were divided into 4 groups randomly.3,4 -dihydro-5- [ 4- ( 1 -piperidinyl) butoxy ] - 1 ( 2H ) - isoquinolinone ( DPQ ),an inhibitor of PARP,was used to inhibit the expression of PARP in rat's heart.The expression of PARP,heart infarct size,heart function,and apoptosis of the cardiomyocytes were detected of different groups of the rats.Results The expression of PARP increased in rat heart I/R injury.Mter DPQ was used,the expression of PARP decreased significantly(5.04 ± 1.25 vs 2.33 ± 0.65,t =1.35,P ＜ 0.05 ) ; inhibition of the expression of PARP improved the cardiac function; inhibition of the expression of PARP decreased cells apoptosis from (34 ± 6.2) ％ to (323 ± 3.8) ％ ( t =2.25,P ＜ 0.05).Conclusions The expression of PARP increased in rat heart I/R injury.Inhibition of the expression of PARP could protect the heart from I/R injury.
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